See also Cephalosporins Organs and systems Nervous system Pseudotumor cerebri has been attributed to ceftriaxone [ ]. Metabolism Although possible interference with the metabolism of carnitine by pivaloylmethyl-esterified beta-lactams is a matter of concern [ ], new similar prodrug derivatives…
General information Adverse effects can arise from physical effects of catheters used for intravenous, intra-arterial, urinary, or spinal access. Adverse reactions can also occur from the latex that some catheters contain or from the antiseptics with which they are sometimes…
General information Caspofungin is approved in patients over 18 years of age for second-line therapy of definite or probable invasive aspergillosis, for primary therapy in non-neutropenic patients with invasive Candida infections, and for empirical antifungal therapy in granulocytopenic patients with…
See also Beta-adrenoceptor antagonists General information Carvedilol is a highly lipophilic non-selective beta-adrenoceptor antagonist with alpha1-blocking action, promoting peripheral vasodilatation. It also has free radical scavenging and antimitogenic effects. The safety and tolerability profile of carvedilol in heart failure appears…
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General information Carnitine Carnitine is a quaternary ammonium compound that is essential in transporting fatty acids from the cytosol into the mitochondria during lipid catabolism. It is found in high concentrations in red meat and dairy products. Other sources include…
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General information Carisoprodol is a precursor of meprobamate, an oral anxiolytic with similarities to benzodiazepines. The spasmolytic effect of carisoprodol is thought to be due to interruption of neuronal communication within the reticular formation and spinal cord. Major adverse effects…
General information Many aspects of the pharmacology, clinical pharmacology, and adverse effects, adverse reactions, and interactions of cardiac glycosides have been reviewed [ ]. Note on nomenclature The most commonly used cardiac glycosides, digoxin and digitoxin, are derived from foxgloves,…
General information Carboxypeptidases are regulatory peptide-processing enzymes that are secreted by human cells [ ]. Carboxypeptidase G2, which is produced by Pseudomonas strain RS-16, hydrolyses the glutamate residue from methotrexate and other folate analogues [ ] and rapidly hydrolyses methotrexate…