Introduction Breast cancer and prostate cancer are the most frequently diagnosed cancers of women and men, respectively, living in developed countries with more than 1 million new cases per year worldwide. Despite the progresses made in the development of new…
Research highlights The epigenome defines cellular identity and is frequently dysregulated in primary bone cancers Aberrant epigenetic modifications in these cancers are promising drug targets Epigenetic heterogeneity is a characteristic of primary bone cancers Novel technologies for analyzing epigenetic heterogeneity…
Abbreviations BAP Serum bone alkaline phosphatase BMD Bone mineral density BSP Bone sialoprotein CTX-I Epitope of C-terminal cross-linked telopeptide of collagen type I DPD Deoxypyridinoline ICTP Epitope of C-terminal cross-linked telopeptide of collagen type I LSC Least significant change MGUS…
Introduction Several cancers are well characterized for their predilection to invade bone, from which breast cancer (BCa), prostate cancer (PCa), and lung cancer (LCa) are on top of the list. It is estimated that ~70% of the patients with PCa…
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Introduction Epithelial—mesenchymal transition (EMT) was originally described as a fundamental process essential for developmental programs including formation of mesoderm, neural crest, heart valve, palatogenesis, and myogenesis [ ]. During the EMT process, the epithelial cells transition from polarized, cobblestone-like cells…
Research highlights High diversity of metabolic fuels to feed bone tumor. Strong energetic metabolism genes program allow tumor cells to survive and progress in bone microenvironment. Osteomimicry may contribute to bone tumor adaptation to their metabolic environment. Introduction Bone tumors…
Research highlights Hypoxia in the primary tumor, as well as low levels of oxygen in the bone marrow, increases the risk of bone invasion. HIF-induced genes in primary tumors (e.g., LOX, PKM2) specifically direct metastasis to bone sites. Hypoxia downregulates…
Introduction Intratumor extracellular proton accumulation is a well-established hallmark of malignancy in solid tumors [ ]. Similarly to hypoxia [ ], acidosis influences the behavior of cancer cells and the clinical outcome by modulating tumor stemness, invasion, invadopodia formation, metastasis,…
Abbreviations 2-AG 2-Arachidonoylglycerol ACEA Arachidonyl-2-chloroethylamide CB1 Cannabinoid receptor type 1 CB2 CB type 2 CB Cannabinoid CBD Cannabidiol Endocannabinoid Endogenous cannabinoid FAAH Fatty acid amide hydrolase GFP Green fluorescent protein IC50 Half-maximal inhibitory concentration MAGL Monoacylglycerol lipase Micro-CT Micro–computed tomography…