Bone sarcoma malignancies: origin, treatment, and diagnosis Bone sarcomas are rare, highly heterogeneous oncologic entities that originate in mesenchymal tissues from bone. Primary bone cancers account for less than 0.2% of all cancers. The high morphological heterogeneity of cancer cells…
Research highlights lncRNAs promote tumorigenesis, chemotherapeutic resistance, and metastasis in bone sarcomas. Notable examples include MALAT1, TUG1, XIST, NEAT1, SNHG12, and UCA1. lncRNAs have emerged as promising diagnostic and prognostic biomarkers, as well as veritable therapeutic targets in bone sarcomas.…
Introduction Cancer metastasis occurs when cancer cells from a primary tumor spread to distant organs, with bone being one of the most common sites for breast, prostate, and lung cancers [ ]. Patients with secondary bone tumors usually show osteolytic…
Introduction Breast cancer and prostate cancer are the most frequently diagnosed cancers of women and men, respectively, living in developed countries with more than 1 million new cases per year worldwide. Despite the progresses made in the development of new…
Research highlights The epigenome defines cellular identity and is frequently dysregulated in primary bone cancers Aberrant epigenetic modifications in these cancers are promising drug targets Epigenetic heterogeneity is a characteristic of primary bone cancers Novel technologies for analyzing epigenetic heterogeneity…
Abbreviations BAP Serum bone alkaline phosphatase BMD Bone mineral density BSP Bone sialoprotein CTX-I Epitope of C-terminal cross-linked telopeptide of collagen type I DPD Deoxypyridinoline ICTP Epitope of C-terminal cross-linked telopeptide of collagen type I LSC Least significant change MGUS…
Introduction Several cancers are well characterized for their predilection to invade bone, from which breast cancer (BCa), prostate cancer (PCa), and lung cancer (LCa) are on top of the list. It is estimated that ~70% of the patients with PCa…
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Introduction Epithelial—mesenchymal transition (EMT) was originally described as a fundamental process essential for developmental programs including formation of mesoderm, neural crest, heart valve, palatogenesis, and myogenesis [ ]. During the EMT process, the epithelial cells transition from polarized, cobblestone-like cells…
Research highlights High diversity of metabolic fuels to feed bone tumor. Strong energetic metabolism genes program allow tumor cells to survive and progress in bone microenvironment. Osteomimicry may contribute to bone tumor adaptation to their metabolic environment. Introduction Bone tumors…