Introduction Soft tissue sarcomas are a heterogeneous group of neoplasms arising in mesenchymal tissue. There are more than 35 histologic subtypes, often associated with distinctive clinicopathologic features. Based on advances in our knowledge of the molecular pathogenesis of these tumors…
Cancer of the thyroid is the ninth most common malignancy diagnosed worldwide in women and 18th in both genders. In the United States, the incidence has been rising faster than that of any other malignancy; in 2012, overall incidence is…
Introduction The mapping of the human genome, and more recently the unraveling of human cancer–specific genomes, has led to more detailed understanding of carcinogenesis, cancer growth, progression, and metastasis. With this understanding, new treatment paradigms for cancer have been developed,…
Acknowledgments Because of the breadth of this review, we apologize for the unavoidable exclusion of references to work done by many outstanding investigators working in these areas. We acknowledge Professor Andrzej Dlugosz for advice on BCC pathogenesis. Skin Cancer Research…
Malignant primary tumors of the central nervous system (CNS) occur in about 25,500 individuals and account for an estimated 13,700 deaths in the United States annually, a mortality rate of 6.5 per 100,000. Based on most recent reports, benign tumors…
Kidney cancer is one of the 10 most common cancers in the United States in both men and women. A number of subtypes of kidney cancer exist. Historically these subtypes have been recognized based on their histological appearance, but it…
Prostate cancer is the most common noncutaneous malignancy and the second leading cause of cancer death in men in the United States. Prostate-specific antigen (PSA) screening began in the late 1980s and dramatically increased the diagnosis of this disease. An…
Acknowledgments These studies were supported in part by a grant from the National Cancer Institute R01 CA135354 , by the M.D. Anderson SPORE in Ovarian Cancer NCI P50 CA83639, the Shared Resources of the M.D. Anderson CCSG NCI P30 CA16672,…
Acknowledgments This work was supported in part by research grants from the NIH/National Cancer Institute R01CA94118 (AVL), R01097213 (SO), the Breast Cancer Research Foundation (SO and NED), Susan G. Komen for the Cure (AVL), the Pennsylvania Department of Health (AVL…
The most common exocrine pancreatic neoplasm is pancreatic ductal adenocarcinoma, which accounts for more than 95% of all pancreatic malignancies. Other pancreatic malignant neoplasms include acinar cell carcinoma, serous cystadenocarcinoma, mucinous cystadenocarcinoma, intraductal papillary-mucinous neoplasm, osteoclast-like giant cell tumor, solid…