Introduction Gastroparesis, also called delayed gastric emptying, is a chronic digestive condition where the stomach fails to properly empty, causing sometimes debilitating symptoms, including nausea, vomiting, pain, and distention/bloating, which persist or reoccur long-term. It can significantly interfere with the…
Introduction In gastroparesis, there is abnormal function of extrinsic vagal innervation, smooth muscle, enteric nervous system, or pacemakers in the stomach wall, specifically, the interstitial cells of Cajal (ICCs) or fibroblast-like cells that have receptors for platelet-derived growth factor α.…
Introduction Normal gastric motor function requires coordinated interaction between the central nervous system (CNS), the enteric nervous system (ENS), interstitial cells of Cajal (ICC), and smooth muscle cells (SMCs). Gastroparesis is a multifactorial neuromuscular disorder involving dysfunction at various levels…
Introduction Gastroparesis (Gp) is a syndrome characterized by delayed gastric emptying in the absence of mechanical obstruction and it is associated with symptoms of early satiety, nausea, vomiting, abdominal pain, and bloating. However, these identical symptoms can occur in patients…
Key points Epidemiological studies show that the incidence of gastroparesis in women is four times higher than men. Female sex hormones fluctuate during different hormonal stages including the menstrual cycle, pregnancy, and menopause raising the theory that differences in gonadal…
Case study HM is a 34 year old woman sent for a third opinion in gastroenterology. Her symptoms include near daily nausea, epigastric fullness, early satiety and bloating. Symptoms started two years ago after she, and the rest of the…
Abbreviations EFTB endoscopicfull-thickness biopsy EMR endoscopic mucosal resection FTRD full-thickness resection device ICC interstitial cells of Cajal MP muscularis propria OTSC over-the-scope-clip Introduction Gastroparesis is a syndrome of delayed gastric emptying in the absence of mechanical obstruction. Common symptoms of…
Introduction The sine qua non of gastroparesis is delayed gastric emptying but as currently defined, gastroparesis is likely a heterogeneous disorder in which symptom pathogenesis is triggered by multiple discrete and connected mechanisms, with delayed gastric emptying representing an epiphenomenon…
Introduction Gastroparesis is a symptomatic condition of delayed gastric emptying with no mechanical obstruction . There are several etiologies of gastroparesis, including diabetic gastroparesis and postsurgical gastroparesis. In many patients, a cause cannot be found, and the condition is termed…
Introduction The NIH Gastroparesis Clinical Research Consortium (GpCRC) was started in 2005 to improve the understanding of the pathogenesis and natural history of gastroparesis of all etiologies and to advance the diagnosis and therapy of patients affected with this troubling…