Key points 1. The neonatal period is a highly dynamic period of gastrointestinal growth and functional development, and physiological changes during the fetal-neonatal period facilitate the transition from placental nutrient assimilation to oral ingestion via the gastrointestinal tract. 2. The…
Key points 1. Bidirectional signaling occurs between the brain and intestine. 2. Microbes in the intestinal tract play a major role in the regulation of this signaling. 3. Disruption of these signaling processes can have a major effect on brain…
Key points 1. Exposure of the intestine to certain microbes and/or their components and metabolites has implications for the future health of the individual as well as implications across generations via epigenetic mechanisms. 2. Responses of the host to the…
Key points 1. In addition to being a digestive absorptive organ, the gastrointestinal tract is also one of the largest immune organs of the body. It is normally inhabited by commensal microbes and is exposed to a prodigious dietary antigen…
Key points 1. Structural and functional development of gut motility in human infants is a process in continuum and varies with birth gestation, postnatal age, nutritional methods, acute illnesses and/or their treatments, comorbidities, and genetic factors. The entire process is…
List of Abbreviations CAN Colitis-associated neoplasia CD Crohn's disease CI Confidence interval CMV Cytomegalovirus CRE Controlled radial expansion CT Computed tomography EBD Endoscopic balloon dilation ECF Enterocutaneous fistula EEF Enteroenteric fistula ELS Electrolyte solution EMR Endoscopic mucosal resection ES Endoscopic…
List of Abbreviations CD Crohn's disease CDI Clostridium difficile infection CMV Cytomegalovirus CRP C-reactive protein DSMB Data Monitoring and Safety Committee FDA The Food and Drug Administration FMT Fecal microbiota transplantation IBD Inflammatory bowel disease NOD2/CARD15 Nucleotide-binding oligomerization domain-containing protein…
List of Abbreviations ASGE The American Society for Gastrointestinal Endoscopy CD Crohn's disease DBE Double-balloon endoscopy EBD Endoscopic balloon dilation ECCO The European Crohn's and Colitis Organisation EGD Esophagogastroduodenoscopy GI Gastrointestinal IBD Inflammatory bowel disease IPAA Ileal pouch-anal anastomosis NKSt…
List of Abbreviations APC Argon plasma coagulation BAE Balloon-assisted enteroscopy CD Crohn's disease CI Confidence interval CMV Cytomegalovirus CRC Colorectal cancer GI Gastrointestinal IBD Inflammatory bowel disease IPAA Ileal pouch-anal anastomosis NSAID Nonsteroidal antiinflammatory drugs OR Odds ratio PSC Primary…
List of Abbreviations AGA The American Gastroenterological Association CD Crohn's disease CI Confidential interval ECCO European Crohn's and Colitis Organisation POCER Postoperative Crohn's endoscopic recurrence TNF Tumor-necrosis factor Introduction Many patients with Crohn's disease (CD) will require intestinal resection surgery…