See also Tricyclic antidepressants General information Doxepin is a tricyclic antidepressant that has also been used topically in the treatment of atopic dermatitis and other forms of eczematous dermatitis. It causes the adverse effects that one would expect, and systemic…
See also Alpha-adrenoceptor antagonists General information The α 1 -adrenoceptor antagonist doxazosin has similar adverse effects to those of prazosin. In a review of its clinical pharmacology and therapeutic uses, reports of tolerability included an update from previously unpublished pooled…
General information Generalized stimulation of the central nervous system has been observed with doxapram, particularly in large doses. Adverse reactions have included hyperactivity, tachycardia, increased deep tendon reflexes and muscle twitching, and laryngospasm. Raised blood pressure can also occur. Doxapram…
General information Doxacurium chloride is a long-acting non-depolarizing neuromuscular blocking agent. It is a bisquaternary benzylisoquinolinium derivative (a diester). It is subject to minimal hydrolysis by plasma cholinesterase (at about 6% of the rate of hydrolysis of suxamethonium when incubated…
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General information Dornase alfa is human recombinant deoxyribonuclease. Daily therapy with dornase alfa in patients with cystic fibrosis can reduce the frequency of respiratory infections and improve lung function in patients with bronchiectasis. You’re Reading a Preview Become a Clinical…
General information Dopexamine, which is related structurally to dopamine, is a potent β 2 -adrenoceptor agonist and dopamine D 1 receptor agonist, which is a vasodilator at low doses, with beneficial effects on splanchnic blood flow, and a vasconstrictor at…
General information Dopamine is a naturally occurring catecholamine and central neurotransmitter capable of raising cardiac output, reducing peripheral resistance, and specifically increasing renal blood flow. Infusions (generally up to 10 micrograms/kg/hour) have proven valuable in shock and congestive heart failure.…
General information The approval of donepezil in several countries in America and Europe has been hailed as a major milestone, because it has met regulatory guidelines for the approval of anti-dementia drugs [ ]. Donepezil belongs to a piperidine class…
General information Domperidone is a neuroleptic antiemetic, a dopamine receptor antagonist. It produces the expected range of dystonic and extrapyramidal adverse effects [ ], which seem, as with metoclopramide, to be more likely to occur in children [ ]. It…