General information Since the withdrawal of hexachlorophene from the non-prescription drug market in the USA, the antiseptic chloroxylenol, which is less antigenic, has been a substitute in a large number of products. Organs and systems You’re Reading a Preview Become…
General information Chlorotrianisene is a non-steroidal triphenylethylene with estrogen and antiestrogen activity. Diethylstilbestrol and other non-steroidal estrogens came into vogue at a time when the cost of producing steroidal estrogens, whether synthetic or of natural origin, was still prohibitive. They…
General information Chloroquine is rapidly and almost completely absorbed from the intestinal tract, peak serum concentrations being reached in 1–6 hours (average 3 hours). It is extensively distributed and redistribution follows. It is slowly metabolized by side-chain de-ethylation. The half-life…
See also Anesthetics, local General information Chloroprocaine is a local anesthetic, an aminoester of para-aminobenzoic acid. Its systemic toxicity is low, owing to rapid hydrolysis by plasma pseudocholinesterases [ ]. Drug studies Comparative studies Chloroprocaine was compared with lidocaine in…
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
General information Chlormezanone is a tranquillizer with central muscle relaxant effects. In reaction to some case reports of serious, sometimes fatal, cutaneous toxicity and after intervention by drug regulatory authorities in some European countries, all major manufacturers have stopped production…
General information Chlorhexidine (1,1′-hexamethylene- bis [5-( p -chlorophenyl)biguanide]) is a widely used antibacterial agent with activity against Gram-positive bacteria, Gram-negative bacteria (less against Pseudomonas species), and yeasts. It was introduced as an antiseptic in the early 1950s. It has been…
See also Benzodiazepines General information Chlordiazepoxide, which has a long duration of action (half-life = 10–25 hours), is useful for the management of alcohol withdrawal and is arguably better tolerated than other benzodiazepines when used for this indication. As with…
See also Thiamphenicol General information Chloramphenicol is one of the older broad-spectrum antibiotics. It was introduced in 1948 and grew in popularity because of its high antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, Rickettsiae , Chlamydia…
See also Dichloralphenazone General information Chloral hydrate, which was synthesized by Justus Liebig in 1832, continues to be used for sleep disorders and for sedation before surgery or radiology, especially in children [ ]. As an alternative to the benzodiazepines,…