Summary of Key Points Discussed are tumor factors that affect treatment responses and outcome and host genetic elements that affect drug metabolism. Only pharmacogenomics elements that interact with chemotherapeutic agents are described. Prognostic biomarkers describe a specific tumor characteristic that…
Summary of Key Points Maintenance therapy offers the possibility of continued active treatment to delay disease progression and symptom deterioration and, more importantly, improved overall survival of patients with advanced nonsmall cell lung cancer (NSCLC) already treated with induction chemotherapy.…
Summary of Key Points There are a growing proportion of patients who are candidates for second-line therapy and beyond. Treatment choices are dictated by tumor histology, molecular phenotype (e.g., EGFR , ALK , ROS1 , etc.), and components of frontline…
Summary of Key Points The determination of tumor histology in nonsmall cell lung cancer (NSCLC) has become essential in treatment decision-making due to differential efficacy and toxicities seen with newer therapies. International Association for the Study of Lung Cancer (IASLC)…
Summary of Key Points Radiation-induced brachial plexopathy (RIBP) occurs with treatment of apical tumors and is frequently complicated by tumor-related brachial plexopathy (TRBP). Stereotactic ablative radiotherapy (SABR) of apical tumors, which employs a higher dose per fraction, can cause RIBP…
Summary of Key Points The acute and late toxicity of radiotherapy (RT) for lung cancer usually involves the lungs, esophagus, and heart. Lung Post-RT, there are multiple biochemical and molecular events involving type II pneumocytes, surfactant protein transudation into alveolar…
Summary of Key Points Palliative radiotherapy is an effective and well tolerated treatment for palliation of thoracic and other symptoms in patients with lung cancer (both nonsmall cell lung cancer and small cell lung cancer). There is ample high-quality evidence…
Summary of Key Points In patients with clinically nonmetastatic small cell lung cancer (SCLC), positron emission tomography–computed tomography (PET–CT) as well as brain imaging is suggested to classify tumor stage. To classify stage, it is recommended to use the Veterans…
Summary of Key Points Concerning radiotherapy, higher physical or biologic dose (altered fractionation) is associated with better local control and, in some trials, with better survival. Current evidence favors a schedule of 60 Gy to 66 Gy in 6 weeks…
Summary of Key Points Since the initial identification of radiofrequency ablation (RFA) as the prototypical thermal ablation technique, it has been joined by microwave ablation, cryoablation, and, more recently, irreversible electroporation as potential options for tumor ablation. Factors that influence…