Colorectal cancer (CRC) development is a complex process. Causal agents and mechanisms include environmental and dietary factors and inherited and somatic mutations. Great progress has been made over the past 30 years toward defining the constellation of molecular alterations contributing…
Epidemiology and Clinical Considerations Head and neck squamous cell carcinoma (HNSCC) arises in the oral cavity, oropharynx, hypopharynx, and larynx. It accounts for more than 90% of the cancers of the head and neck and is the sixth most common…
Acknowledgments We thank the many current and past members of the Minna lab for their contributions to lung cancer translational research and our especially our long-term collaborator, Dr. Adi Gazdar. Also we apologize to other investigators for the omission of…
Introduction The cancers arising from the esophageal mucosa, primarily esophageal adenocarcinoma (EAC) and esophageal squamous-cell carcinoma (ESCC), are clinically some of the most devastating and lethal cancers in the world. Collectively, they are the eighth most common cancer diagnosed worldwide,…
Acknowledgments Dr. G. Tonon acknowledges the support from the Associazione Italiana per la Ricerca sul Cancro (AIRC), the Association for International Cancer Research (AICR), and the Cariplo Foundation and is a recipient of a Marie Curie International Reintegration Grant. Dr.…
The lymphoid malignancies comprise one of the most diverse and heterogeneous sets of diseases that exist under a single type of malignancy. In 2012, the American Cancer Society estimated there were about 70,000 cases of non-Hodgkin lymphoma (NHL), and about…
Introduction The genesis of human myeloid leukemia involves the deregulation of the differentiation and maturation programs of the hematopoietic myeloid lineage that originates from primitive stem cells with multilineage potential. Myeloid leukemias have been linked to the acquisition of chromosomal…
Cancer is the most common cause of disease-related death in children beyond the newborn period. Although childhood cancers, as a group, account for only a small proportion of all human cancer, their unique biologic features, cell of origin, and response…
Introduction Acute lymphoblastic leukemia (ALL) is a sharply contrasting disease in the pediatric and adult populations. In children, it is both the most common leukemia and the most common malignancy. Childhood ALL has been emblematic of medical progress, with steady…
Acknowledgments This work was supported in part from research grants from the State of Pennsylvania Tobacco Funds (DLT), NIH R01 GM075205IH (RFM), NIH-NIGMS R01 GM086238 (TL, Ivet Bahar, PI), NIH-NCRR UL1RR024153-05 (TL and JRF, Steve Reiss, PI), and NIH-NCI 1R21CA164433-01A1…