Cannulation of Arteriovenous Vascular Access: Science and Art


Introduction

The delivery of hemodialysis (HD) therapy for a patient with an arteriovenous (AV) vascular access is dependent on successful vascular access cannulations. A typical in-center HD patient requires routine cannulation for 156 treatments per year. Despite the high frequency of cannulation, limited randomized controlled trials (RCTs) provide the scientific aspect. The art of cannulation is the skill part of the procedure. Nephrologists oversee the overall care, including cannulation. Nephrology nurses and nephrology clinical technicians provide direct patient care, including initial and routine cannulation.

Access Monitoring

The simple One Minute Check should be performed before every HD access cannulation. A Fistula First Work Group created the One Minute Check. It mimics the simple cardiopulmonary resuscitation (CPR) check of “look, listen, and feel” before starting CPR. The simple check can avoid the cannulation of thrombosed access. Cannulation of thrombosed access may lead to bleeding at the puncture site during the thrombectomy procedure. Assessment of the access must occur before cannulation. The simplification of the check was intentional to allow the patient, family or care partner, and patient care technicians to perform the check. In the United States, the technician may be restricted from making a clinical assessment but can perform a check. Normal findings are a green light to process with the cannulation procedure. Abnormal findings are considered a red stop sign to pause the cannulation and escalate to the registered nurse. The nurse can then utilize the expert level One Minute Check for additional assessment. The expert level is an expanded check that includes the augmentation test at the expert level for the dialysis care team members—including the nephrologist and advanced practice team members. State laws for the scope of practice vary by state.

The 2019 Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline for Vascular Access 2019 Statement: Vascular Access General Monitoring 11.1 KDOQI considers it reasonable to assess or check the vascular access prior to every cannulation (if AV access) or connection (if central venous catheter [CVC]) for potential complications. Refer to Table 16.1 .

Table 16.1
KDOQI Physical Examination (Monitoring) Related Practice Guidelines
  • 13.1 KDOQI recommends regular physical examination or check of the AVF, by a knowledgeable and experienced health practitioner, to detect clinical indicators of flow dysfunction of the AVF. (Conditional/Strong Recommendations, Moderate Quality of Evidence)

  • 13.2 KDOQI recommends regular physical examination or check of the AVG, by a knowledgeable and experienced health practitioner, to detect clinical indicators of flow dysfunction of the AVG. (Conditional/Strong Recommendations, Moderate Quality of Evidence)

  • 13.3 KDOQI considers it reasonable for nephrology trainees and health practitioners involved with clinical HD patient care to be properly trained in physical examination of the AV access to monitor for and detect AV access flow dysfunction. (Expert Opinion)

AV , Arteriovenous; AVF , arteriovenous fistula; AVG , arteriovenous graft; HD , hemodialysis; KDOQI , Kidney Disease Outcomes Quality Initiative.

The patient One Minute Check version is available for AV fistula (AVF), AV graft (AVG), and HD catheters. The One Minute Check is intended for the patient/family/care partner to do daily and to report any abnormal findings to the dialysis care team.

The Augmentation Test is at the expert level and is a simple, noninvasive means of detecting an inflow issue. A common cause of a new AVF to fail to mature is the development of juxta-anastomotic stenosis that develops just above the anastomosis. The stenosis inhibits the access flow and thus reduces the main fistula outflow vessel dilatation.

The novice and expert One Minute Check tools (AVF/AVG/catheter) are available online at https://esrdncc.org/en/resources/lifeline-for-a-lifetime/step-eight-the-one-minute-access-check/

The development of outflow stenosis in the AVF or AVG can trigger the sequel of lowered access flow, increase in venous pressures, decrease in the internal access flow, occurrence of recirculation, and reduction in the dialysis adequacy.

The patient/care partner can detect changes in the bruit and thrill by using the daily One Minute Check. The dialysis team members can detect changes in the bruit and thrill by utilizing the One Minute Check prior to each cannulation. Anytime a change is detected, the access should be evaluated with the expert level One Minute Check without the needles inserted. The expert can then determine if the access is useable to initiate the dialysis session. A spot assessment of the clinic-specific policy and procedure for the full monitoring and surveillance can be utilized to confirm the One Minute Check findings. The monitoring and surveillance can include measurement of the access flow, recirculation, review of venous pressure, prepump negative pressure, inability to achieve the prescribed blood flow rate, and/or prolonged bleeding post needle removal, as a few examples ( Table 16.2 ).

Table 16.2
Combined Physical Exam/Monitoring Check
One Minute Check (Novice/Expert), Vascular Access 2018 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS) and 2019 KDOQI Vascular Access Guidelines

Exam or Check Step Fistula Normal
Green Light
Graft Normal
Green Light
Flow-Related Dysfunction or Poor Maturation (Abnormal)
Red Light
Infection, Steal Syndrome, or Aneurysm/Pseudo-aneurysm (Abnormal)
Red Light
Look The skin over the access is all one color and looks like the skin around it.
Well-developed main venous outflow, no irregular/dilated areas or aneurysm formations, adequate areas of straight vein that can be used for two-needle, rope ladder cannulation.
Pulse does not become more forceful or “strong and bounding.”
Uniform-sized graft in a loop or straight configuration. No irregular areas or aneurysm or seroma formations with organized site rotation used for cannulation.
Presence of swelling.
Rich collateral veins.
AVF with poor maturation—multiple venous outflow veins (accessory veins), poorly defined cannulation areas.
AVF: Stenosis can occur in artery or any venous outflow vein. Look for a narrowing of the outflow vein, abnormal pulsations, or aneurysm formation.
AVF or AVG: Dilated neck veins or surface collateral veins in the arm or neck above the vascular access.
There is redness, swelling, or drainage. There are skin bulges with shiny, bleeding, or peeling skin.
Ischemic fingers: Fingertip wounds like paronychia
Aneurysms: Nonhealing crust over the puncture site.
Infection: Redness, swelling, induration, drainage, or pus
Steal syndrome: Extremity/hand discoloration, skin ulceration due to poor arterial blood flow to the hand. Check nail beds, fingers, and hand for unusual skin changes
Aneurysm: Abnormal areas of dilatation with overlying skin thinning
Listen Bruit—the hum or buzz should sound like a “whoosh,” or for some may sound like a drumbeat. The sound should be the same along the access.
Low-pitch continuous diastolic and systolic.
Bruit—the hum or buzz should sound like a “whoosh,” or for some may sound like a drumbeat. The sound should be the same along the access.
Low-pitch continuous diastolic and systolic.
There is no sound, decreased sound, or a change in sound. Sound is different from what a normal bruit should sound like.
Strictures can be palpated and the intensity and character of the bruits can suggest the location of stenoses. (AVF)
A local intensification of bruit over the graft or the venous anastomosis compared with the adjacent segment suggests a stricture or stenosis. (AVG)
High-pitch discontinuous systolic only.
AVF may have a very strong bruit.
Feel Thrill: a vibration or buzz in the full length of the access.
Pulse: slight beating like a heartbeat. Fingers placed lightly on the access should move slightly.
Thrill at the arterial anastomosis and throughout the entire outflow vein that is easy to compress
Thrill: a vibration or buzz in the full length of the access.
Pulse: slight beating like a heartbeat. Fingers placed lightly on the access should move slightly.
Thrill strongest at the arterial anastomosis but should be felt over entire graft and be easy to compress.
Pulsatile: The beat is stronger than a normal pulse. Fingers placed lightly on the access will rise and fall with each beat.
Rich collateral veins
A strong pulse and weak thrill in the vein central to the anastomosis indicates a draining vein stenosis.
A strong pulse and weak thrill in the vein central to the anastomosis indicates a draining vein stenosis.
AVF: Pulse at the site of a stenotic lesion—may be water-hammer in quality and feel.
AVG: Thrill and/or pulse strong at the site of stenotic lesion pulse has a water-hammer feel. An AVG with a low intra-access blood flow feels mushy. Local area of the graft that feels mushy or irregular in shape can be a site of aneurysm formation.
Ischemic fingers
Aneurysms
Infection: Warm or painful to touch, swelling
Steal syndrome: Feel bilateral limbs (hands and fingers) and compare for the access limb to be the same as the nonaccess limb. Compare temperature, grip strength, and range of motion and any complaints of changes in sensation or pain. If the access limb has any major differences than the nonaccess limb, consider steal syndrome
Arm elevation test Upper arm AVF: Arm elevation. The AVF outflow vein partially collapses when the arm is raised above the level of the heart. It may feel “flabby” when palpated.
Lower arm AVF: The AVF outflow vein collapses when arm is raised above the level of the heart.
Vessel collapses when the arm is elevated above head
Normal
Upper arm AVF: The AVF outflow vein does not partially collapse or become “flabby” after being raised above the level of the heart. This finding should be reported to an expert clinician.
Lower arm AVF: The AVF outflow vein does not collapse after being raised above the level of the heart. This finding should be reported to an expert clinician.
A fistula that does not at least partially collapse with arm elevation is likely to have an outflow stenosis.
Vessel collapses when arm is elevated above head.
Augmentation test Pulse should be “strong and bounding” and may cause your finger to rise and fall with each beat Pulse does not become more forceful or “strong and bounding”.
Dialysis observations:
New difficulty with cannulation when previously not a problem.
Aspiration of clots.
Inability to achieve the target dialysis blood flow.
Prolonged bleeding beyond usual for that patient from the needle puncture sites for three consecutive dialysis sessions.
Unexplained (> 0.2 units) decrease in the delivered dialysis dose (Kt/V) on a constant dialysis prescription without prolongation of dialysis duration.

AVF , Arteriovenous fistula; AVG , arteriovenous graft.

General Process of Care Related to Cannulation

The process of care for HD varies significantly by geographic staffing patterns. The U.S. staffing pattern is highly dependent on the direct care role of the patient-care technicians. The minimum qualifications for technicians include a high school diploma. The training is on-the-job training. The nurses direct the care delivered by technicians. Care includes cannulation, the procedure to initiate HD, monitoring HD treatment, and the procedure to terminate HD treatment. Outside the United States, the role of technicians is limited. Direct care is typically provided by nurses. The ratio of staff members to patients also varies significantly by geographic location. Sample staff patterns in the United States may be one nurse to several technicians, with one technician assigned to cover three to four patients each. The skill level of nurses for cannulation is commonly limited as the nurses are mainly dealing with patient assessments and HD catheter care (in states that prohibit technicians from initiating/terminating the HD treatment). Thus, the local practice patterns determine the vascular access and cannulation process of care.

Staff is assigned time for different procedure steps to initiate dialysis treatment for a single patient. The time allotment often does not include additional time for assessment of the vascular access or troubleshooting of the cannulation procedure. The staff member is expected to complete the dialysis initiation procedure within the time allotment and then move to the next patient. Should the staff member exceed the time allotment with one patient, initiation of dialysis for the subsequent patients can be delayed. The snowball effect of delays commonly leads to staff stress and patient frustration and is a common root cause of negative patient and staff interactions.

The initial vascular access cannulation can exceed the typical time allotment of the dialysis initiation per patient. The staff assignment needs to be adjusted to allow the staff to take the extra time required to cannulate the vascular access successfully. Patients fear of needles and stress triggered by their first-ever cannulation procedure may require additional emotional support from the care team. One suggestion can be to move the patient with the first-ever cannulation to be the last patient assignment for the staff member of the specific shift. The change in time can allow for a more extended time allotment without causing a ripple effect of delays. It can also let two staff members be Chairside for the initial cannulation. The cannulator can focus on the cannulation. The second staff member can focus on supporting the patient while also being available for immediate assistance for troubleshooting any cannulation difficulties. The concept can also facilitate the use of point-of-care ultrasound (POCUS).

HD patients are typically dialyzed in a reclining chair. The position of the cannulator for the actual needle insertion can also impact the cannulation success. Standing is a typical positioning of the staff member for cannulation procedure, and this position can generate a downward force from the cannulator’s body to the AVF needle. The downward force can lead to the sharp needle bevel cutting the vessel and then going into the back wall leading to a backwall infiltration. If the cannulator sits on a stool to be level with the vascular access, the downward pressure is easier to control. It also places the staff member at eye level to the patient and can reduce the fear/anxiety of the patient ( Table 16.3 ).

Table 16.3
Cannulation-Related Practice Guidelines
Guideline Reference Guideline Statement
2019 KDOQI Vascular Access Guideline 11.6 KDOQI considers it reasonable to use skilled cannulators with established high rates of cannulation success to perform initial AV access cannulations on patients to help avoid primary infiltration injury of the AV access. (Expert Opinion)
2019 KDOQI Vascular Access Guideline 11.7 KDOQI considers it reasonable to have structured training and supervision of dialysis technicians and nurses before and during their initial cannulation attempts, and regular training updates to maintain cannulation competency. (Expert Opinion)
2019 KDOQI Vascular Access Guideline 11.8 KDOQI considers it reasonable to support and educate eligible patients on self-cannulation of their AV access. (AVF or AVG). (Expert Opinion)
2018 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)
6.3.2.2.
Ultrasound-assisted cannulation. The statement supports ultrasound-assisted cannulation to reduce cannulation infiltration related complications. ESVS states randomized controlled trials of ultrasound-guided cannulation versus unassisted cannulation to determine benefit is required. The statement also supports ongoing education and training of the dialysis facility staff on cannulation techniques.
AV , Arteriovenous; AVF , arteriovenous fistula; AVG , arteriovenous graft; KDOQI , Kidney Disease Outcomes Quality Initiative.

Cannulation-Induced Needle Fear or Phobia

Cannulation of patients’ HD vascular access can trigger needle fear or needle phobia. The prevalence of needle fear in dialysis patients ranges from 25% to 55%. Needle phobia has also been cited by 47% of in-center HD patients as a barrier to self-care. A typical in-center HD patient undergoes 312 needle cannulations per year. Home HD therapies often have an even higher number of treatments per week, with a higher resultant number of cannulations per year ( Table 16.4 ).

Table 16.4
Number of Cannulations per Year Based on Dialysis Frequency
Treatment Frequency Needles per Session Weeks in a Year Total Number of Cannulations per Year
3 2 52 312
4 2 52 416
5 2 52 520
6 2 52 624
7 2 52 728
Additional cannulations due to needle insertion complications such as infiltration are not included in the table.

The 2020 ICD-10-CM Diagnosis Code F40.231 defines needle fear or needle phobia as the fear of injections and transfusions. The ICD-10-CM F40 diagnosis code defines phobic anxiety disorders as an irrational fear of something that poses little to no actual physical harm. Exposure to the trigger of the phobia can lead to physical symptoms including panic and fear, rapid heartbeat or palpitations, shortness of breath, trembling or shaking, strong desire to get away from the trigger, dizziness or unsteadiness, nausea, and sweating.

Needle fear prevalence rates vary by age grouping (refer to Table 16.5 ). McLenon and Rogers reported a difference based on sex as females report a higher prevalence of needle fear compared with men. The prevalence of needle fear and phobia in the pediatric HD population ranges from 50% to 100%. Care partners of adult home HD patients or caregivers of pediatric HD patients may also have a fear of needles. Health care workers are not immune to needle fear issues, as 1 in 6 long-term care facilities and 1 in 13 hospital workers avoid annual influenza vaccinations due to fear of needles.

Table 16.5
Prevalence Rates of Needle Phobia by Age Grouping
Age Grouping Prevalence Rates of Needle Phobia
Children 50%–100% decreases with age
Adolescents 20%–50%
Young adults 20%–30%
Adults 16%
Elderly < 5%

The high prevalence of needle phobia in the HD population must be addressed by the dialysis care team. The individualized patient plan of care should include measures to reduce the fear and the triggers of related phobia symptoms. The most common intervention is the use of local topical anesthesia. Table 16.6 includes infection control considerations for each agent. The use of any agent should be individualized for each patient based on the cannulation method (staff cannulation, self-cannulation, rope ladder, or buttonhole). The therapeutic effectiveness should be documented and reviewed as part of the ESKD Life Plan under vascular access type. Should the cannulation method require modification, the pain control measures should be reviewed and updated as needed. Anesthesia agents may require a physician's prescription, and the dispensing process varies by local laws.

Table 16.6
Cannulation Pain Control Measures
Measure to Reduce Needle Fear/Pain Description of Use Infection Control Considerations Other Considerations
Local topical anesthesia such as a lidocaine cream.
Impact on needle phobia: High.
Peds: Can be utilized with pediatric patients. Check drug instructions for use for a minimum age or weight requirements
Follow instructions for use for contact time with the skin to achieve adequate effect of anesthesia on the skin over the needle cannulation sites.
Typically requires application 1 hour prior to the cannulation. Can be applied at home and cover with plastic wrap. Note the maximum recommended duration of exposure is usually 4 hours—check drug instructions for use.
Each patient is given a prescription for their drug and applies the drug at home and not in the hemodialysis environment.
The skin prep steps:
Washing the cream off the cannulation sites with soap and water at the skin prior to sitting into the dialysis chair.
If the patient is unable to wash, the staff should use skin wipes to remove and cleanse the skin.
If utilized with buttonhole cannulation, the cream must be cleansed from the skin prior to the buttonhole scab removal procedure.
Unit-specific skin prep for routine cannulation.
The amount of the topical anesthesia should follow the drug instructions for use to ensure the dosage is below the maximum application area. Check instructions for use for cm 2 as area coverage.
If plastic wrap is applied to cover the cream, the wrap should not impede blood flow in the AV access.
Needle site rotation must be clearly determined to ensure the patient applies the topical anesthesia in various locations allowing proper rope ladder and avoids area puncture.
Intradermal lidocaine.
Impact on needle phobia: Poor as the intradermal injection requires a needle and the lidocaine causes burning sensation when injected.
Injected from a syringe via a small-gauge needle. Should use a separate syringe/needle for intradermal injection.
Skin prep of washing with soap/water as well as the initial skin prep prior to the intradermal injection procedure.
The needle should be a safety needle to prevent accidental needle stick to the cannulator.
Place the patient in the Trendelenburg position for cannulation.
Impact on needle phobia: High in patients with physical manifestations of needle phobia.
Elevation of lower extremities in the recumbent position with applied muscle tension augments the central venous reservoir, increases stroke volume, and helps maintain cerebral perfusion. Chair/dialysis machine positioning to allow the staff member to reach the lower or upper arm cannulation sites with the patient in the Trendelenburg chair position.
Ethyl chloride topical anesthetic skin
Refrigerant
Impact on needle phobia: Moderate as the numbing effect is on the skin surface, not deeper tissue
Spray the cannulation for few seconds—check drug instructions for use for time or until the skin color begins turning white, whichever comes first. The drug is available in both a can and a bottle.
Infection control practices require any item that enters the direct patient station to be surface disinfected or single use only. This can be a barrier to use in the in-center hemodialysis facility.
Alternative measures:
Topical application of lavender
Impact on needle phobia: Limited studies to determine
Topical application of 100% lavender essential oil decreases moderate intensities of pain during needle insertion. Oils are over-the-counter products and thus are not tested or controlled for proper concentration or any contaminants. The oil container must be limited to a single patient to prevent cross-contamination.
Proper skin disinfection should occur after the application of the oil to prevent cross-contamination of the needle site.
AV , Arteriovenous.

Hamilton JG. Needle phobia: a neglected diagnosis. J Fam Pract . 1995;41(2):169-175.

Ghods AA, Abforosh NH, Ghorbani R, Asgari MR. The effect of topical application of lavender essential oil on the intensity of pain caused by the insertion of dialysis needles in hemodialysis patients: a randomized clinical trial. Complement Ther Med . 2015;23(3):325-330.

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