Zakim and Boyer's Hepatology

Pathogenesis of Nonalcoholic Fatty Liver Disease

Abbreviations apoB apolipoprotein B AS160 Akt substrate 160-kDa protein ASC apoptosis-associated specklike CARD domain–containing protein ATF activating transcription factor ATG autophagy-related gene Bad Bcl2-associated agonist of cell death BIP binding Ig protein CD cluster of differentiation CHOP C/EBO homologous protein…

Natural History and Cofactors of Alcoholic Liver Disease

Abbreviations ADH alcohol dehydrogenase AH alcoholic hepatitis AHHS Alcoholic Hepatitis Histologic Score ALD alcoholic liver disease ALDH aldehyde dehydrogenase ALT alanine aminotransferase ANI alcoholic liver disease/nonalcoholic fatty liver disease index AST aspartate aminotransferase CYP2E1 cytochrome P450 2E1 IL-10 interleukin-10 MELD…

Epidemiology and Pathogenesis of Alcoholic Liver Disease

Abbreviations 2-AG 2-arachidonoylglycerol ACC acetyl-CoA carboxylase ADH alcohol dehydrogenase AH alcoholic hepatitis ALD alcoholic liver disease ALDH aldehyde dehydrogenase ALT alanine aminotransferase AMPK AMP-activated protein kinase AP-1 activator protein-1 transcription factor ASH alcoholic steatohepatitis AST aspartate aminotransferase BAC blood alcohol…

Acute-on-Chronic Liver Failure

Abbreviations ACLF acute-on-chronic liver failure ALF acute liver failure HCC hepatocellular carcinoma INR international normalized ratio LT liver transplantation MELD Model for End-Stage Liver Disease SLK simultaneous liver-kidney transplantation Introduction Cirrhosis had traditionally been classified into two stages: compensated cirrhosis…

Acute Liver Failure

Abbreviations ALF acute liver failure APAP acetaminophen BCAA branched-chain amino acid CPP cerebral perfusion pressure GABA γ-aminobutyric acid CRRT continuous renal replacement therapy CVP central venous pressure HAV hepatitis A virus HBV hepatitis B virus HCV hepatitis C virus HDV…

Cardiopulmonary Complications of Cirrhosis

Abbreviations BNP brain natriuretic peptide CBDL common bile duct ligation CCM cirrhotic cardiomyopathy HO-1 heme oxygenase-1 HPS hepatopulmonary syndrome iNOS inducible nitric oxide synthase mPAP mean pulmonary artery pressure PAH pulmonary arterial hypertension POPH portopulmonary hypertension TDI tissue Doppler imaging…

Renal Failure in Cirrhosis

Abbreviations ADQI Acute Dialysis Quality Initiative AKI acute kidney injury AKIN Acute Kidney Injury Network ATN acute tubular necrosis C-AKI cirrhosis–acute kidney injury CKD chronic kidney disease DAMP damage-associated molecular pattern GFR glomerular filtration rate HRS hepatorenal syndrome HRS1 Type…

Portal Hypertension Related to Bleeding

Abbreviations AIDS acquired immunodeficiency syndrome ARPKD autosomal recessive polycystic kidney disease BRTO balloon-occluded retrograde transvenous obliteration of varices DSRS distal splenorenal shunt EMT epithelial-mesenchymal transactivation FHVP free hepatic vein pressure GAVE gastric antral vascular ectasia GVE gastric vascular ectasia HHT…