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Introduction Virtually any tumor can metastasize to the skin, but some do so more often than others. The identification of the primary site is not always easy, and this process is further complicated by the occurrence of primary adnexal tumors…
Introduction A renewed interest in vascular tumors was provoked by the emergence of AIDS-related Kaposi's sarcoma in the 1980s, and since then a number of new entities have been described. Although many of these are rare, they may produce diagnostic…
Introduction Neural tumors are an important category of cutaneous tumors. Although the vast majority of them can be diagnosed without difficulty, there are cases that require distinction from other spindle cell tumors, including melanoma. Markers are still being sought that…
Tumors of Smooth Muscle Smooth muscle is found in the skin in three distinct settings: the arrector pili muscles; the walls of blood vessels; and the specialized muscle of genital skin, which includes the scrotum (dartos muscle), vulva, and nipple…
The role of subcutaneous fat and the consequences of its increase and decrease have received little attention in the dermatological literature until comparatively recently. There are two types of adipose tissue, white and brown, that have different roles in energy…
Introduction Recent immunohistochemical findings have assisted in the histogenetic classification of many of the soft tissue tumors. However, because vimentin is positive in many tumors, it is of no value in the differential diagnosis of tumors discussed in this chapter.…
Introduction The cutaneous appendages give rise to a bewildering number of neoplasms—more than 80 in a recent count. Various classifications have been proposed in the past. Previous classifications have required modification from time to time in light of the most…
Introduction The histopathological diagnosis of pigmented skin tumors is an important area of dermatopathology. Note that melanin pigment may also be present in skin tumors other than nevocellular nevi and melanomas. For instance, seborrheic keratoses, basal cell carcinomas, and, rarely,…