Uropathology

Urothelial carcinoma with rhabdoid differentiation

Definition Unusual variant of urothelial carcinoma characterized by presence of cells with prominent rhabdoid features Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member.…

Urothelial carcinoma with syncytiotrophoblastic giant cells

Definition Unusual form of divergent differentiation in urothelial carcinoma characterized by the presence of human chorionic gonadotrophin (hCG) positive syncytiotrophoblastic giant cells or by a choriocarcinoma component Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full…

Urothelial carcinoma, giant cell variant

Definition Urothelial carcinoma entirely or partially composed of pleomorphic giant cells Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

Lipid-rich urothelial carcinoma

Definition A rare variant of urothelial carcinoma, characterized by the presence of lipoblast-like epithelial tumor cells with lipid-containing cytoplasmic vacuoles Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…

Urothelial carcinoma, clear cell (glycogen-rich) variant

Definition Urothelial carcinoma showing clear cell pattern with glycogen-rich cytoplasm Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

Urothelial carcinoma, lymphoepithelioma-like carcinoma variant

Definition Undifferentiated carcinoma of the urinary bladder with a prominent lymphocytic stroma and morphologic resemblance to the undifferentiated nasopharyngeal carcinoma variant Clinical features Epidemiology The male-to-female ratio is 2:1. Most patients are in late adulthood, with a mean age at…

Urothelial carcinoma, microcystic variant

Definition A histologic variant of urothelial carcinoma that is composed of malignant urothelial nests, usually with low-to-intermediate nuclear grade, with microcyst, macrocyst and tubular formation. Usually occurs in the bladder with rare cases in the renal pelvis Clinical features Epidemiology…

Urothelial carcinoma, micropapillary variant

Definition Morphologically distinct variant of invasive urothelial carcinoma Clinical features Epidemiology Incidence <1% to 2.2% of all invasive urothelial carcinomas Most common in the sixth decade (range, 45 to 91 years) Males more frequently affected (male-to-female ratio, 5:1) You’re Reading…

Urothelial carcinoma, nested variant

Definition A rare variant of urothelial carcinoma composed of cytologically bland cells that infiltrate in individual or crowded nests Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If…

Urothelial carcinoma, plasmacytoid variant

Definition A rare variant of urothelial carcinoma composed of cells that resemble plasma cells and/or monocytes Also known as signet cell or diffuse variant Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy…