Uropathology

Metanephric adenoma

Definition A benign tumor recapitulating differentiation toward early embryonic metanephric tubules; also known as embryonal adenoma or nephrogenic nephroma Clinical features Epidemiology Female predominance Wide age range, from infants to elder individuals You’re Reading a Preview Become a Clinical Tree…

Renal tumors in tuberous sclerosis complex (TSC)

Definition Renal tumors in patients with tuberous sclerosis complex (TSC) Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

Renal cell neoplasms in Birt-Hogg-Dubé (BHD) syndrome

Definition An autosomal dominant syndrome characterized by a constellation of benign skin follicle tumors, multiple renal cell neoplasms, and spontaneous pneumothorax Clinical features Epidemiology Rare autosomal dominant disease with an incidence of 1/36,000 to 1/45,000 Life risk for renal cell…

Renal cell carcinoma in von Hippel-Lindau disease

Definition An autosomal dominant disease caused by germline mutations in the von Hippel-Lindau ( VHL ) tumor suppressor gene on 3p25.3 and characterized by a constellation of tumors including renal cysts and clear cell renal cell carcinoma Clinical features Epidemiology…

Staging of renal cell carcinoma

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Renal cell carcinoma, unclassified type

Definition A group of renal cell carcinomas (RCCs) whose morphology or growth pattern does not readily fit any of the RCC subtypes recognized by the current World Health Organization classification Clinical features Epidemiology Represents 3%–5% of all RCCs The incidence…

Renal cell carcinoma with sarcomatoid differentiation

Definition Sarcomatoid component present in renal cell carcinoma (RCC) of any histologic subtype Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…

Eosinophilic solid cystic renal cell carcinoma

Definition A recently described variant of renal cell carcinoma (RCC) defined morphologically by solid and cystic areas composed of tumor cells with voluminous eosinophilic cytoplasm and basophilic coarse cytoplasmic granules and positive cytokeratin 20 staining Clinical features Epidemiology Incidence currently…