Uropathology

Embryonic testicular regression (Vanishing testis syndrome)

Definition A developmental anomaly in which one or both testicles vanish during embryogenesis in patients with XY karyotype Clinical features Epidemiology Usually sporadic with rare familial instances with recessive trait Unclear etiology, possibly regression of the testes in utero due…

Testicular tumor of the adrenogenital syndrome

Definition Rare clinical entity found in young men with endocrine disorders. Testicular tumor of the adrenogenital syndrome (TTAGS) has also been referred to as testicular adrenal rest tumors (TARTs). TTAGS is most likely hyperplasia and not a true neoplasm. Clinical…

Klinefelter syndrome

Definition Klinefelter syndrome (or 47,XXY or XXY syndrome) is a condition in which males have an extra X chromosome. Clinical features Epidemiology Klinefelter syndrome is the most common sex chromosome disorder in males and the second most common condition caused…

Androgen insensitivity syndrome

Definition Resistance of target organs to androgen stimulation (owing to androgen receptor gene mutation on the X chromosome) leading to several syndromes with phenotypes varying from testicular feminization (severe form) to normal males with infertility (mild form) Clinical features You’re…

Nonspecific granulomatous orchitis

Definition Nonspecific granulomatous orchitis is a rare and unusual disease with mixed chronic and granulomatous inflammation of an unknown etiology. Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…

Granulomatous orchiepididymitis

Definition Granulomatous inflammation of testis and epididymis caused mainly by Mycobacterium tuberculosis Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

Viral orchitis

Definition Viral infection of the testis, most frequently due to mumps virus and Coxsackie B virus. The other viruses that can infect the testis and cause acute orchitis are influenza, infectious mononucleosis, coronavirus, varicella, and others. Clinical features Epidemiology In…

Postpubertal gonadotrophin deficiency

Definition Postpubertal children or adults who have undergone normal pubertal development show testicular regression due to deficiency of gonadotropins, including luteinizing hormone (LH) and follicle stimulating hormone (FSH). Clinical features You’re Reading a Preview Become a Clinical Tree membership for…

Pre-pubertal gonadotropin deficiency

Definition Aspermatogenesis in adolescent or adult males who have never had normal secretion of gonadotropin hormones Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…

Excurrent duct obstruction

Definition Congenital or acquired obstruction of the epididymis, vas deferens, or both, leading to azoospermia or low sperm count Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If…