Definition Malignant germ cell tumor that recapitulates the trophoblastic cells of extraembryonic chorion, including syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast cells Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…
Definition A teratoma develops a distinct secondary somatic (or non-germ cell) malignant component. Clinical features Epidemiology Only in postpubertal patients (age range, 15–68 years) Seen in 3%–6% of germ cell tumors (GCT) containing a teratomatous component You’re Reading a Preview…
Definition Testicular germ cell tumor composed of more than one histologic type of germ cell tumor Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…
Definition GCT in the postpubertal testis composed of several types of somatic-type tissue originating from different germinal layers (endoderm, mesoderm, and ectoderm). It is usually composed of mature (or well-differentiated) tissues, and immature (or embryonic-type) tissues may be seen in…
Definition Germ cell tumor (GCT) in the postpubertal testis composed of malignant epithelial cells recapitulating the extraembryonic structures, such as the yolk sac, allantois, and extraembryonic mesenchyma; also called endodermal sinus tumor Clinical features Epidemiology Patients are typically 15–40 years…
Definition Germ cell tumor (GCT) composed of primitive epithelial tumor cells with marked nuclear atypia and indistinct cell borders, recapitulating an early phase of embryonic development Clinical features Epidemiology Affects young men with a peak age of 30 years, about…
Definition Germ cell tumor (GCT) composed of uniform malignant cells with clear cytoplasm and large round nuclei that are considered the neoplastic counterparts of the primordial germ cells (or gonocytes) during early embryonic development Clinical features Epidemiology Patient mean age,…
Definition Complete filling of seminiferous tubules by neoplastic germ cells, including seminoma and other non-seminomas Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member.…
Definition Gonocyte-like germ cells with abundant clear cytoplasm and large nuclei with coarse chromatin and expressing embryonic germ cell markers, located in the basilar aspect of the seminiferous tubules; considered to be the precursor of the majority of malignant testicular…
Definition Disorder of sex development; congenital developmental defect of one or both gonads and reproductive organs due to either structural or numerical anomalies of the sex chromosomes or mutations in the genes involved in the gonadal development Originally referred to…