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Rheumatic Disease Clinics
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Confidence is ClinicalKey
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Classification and Diagnostic Criteria
The unique role of criteria sets for classification and diagnosis in rheumatology reflects the clinical and scientific challenges characteristic of rheumatic diseases. Rheumatic diseases often cannot be defined by a single clinical, laboratory, radiologic, or pathologic feature because of their…
Bone tumors
Key Points ■ Bone tumors present with pain, swelling, pathologic fracture, or loss of use or as an incidental finding. ■ Urgent investigations of plain radiography, magnetic resonance imaging, or computed tomography are required with formal diagnostic core biopsy. ■…
Hypermobility syndrome
Key Points ■ Joint hypermobility as a clinical entity is difficult to define given current parameters; the Beighton score is not fit for this purpose, and a new measurement tool is required to identify patients with significant global joint laxity.…
Heritable connective tissue disorders
Key Points ■ Heritable disorders of the skeleton and connective tissues are individually rare but collectively constitute an important source of morbidity and mortality. ■ Improved diagnostic classification criteria allow more accurate prognostication for disorders such as Marfan syndrome, Ehlers-Danlos…
Miscellaneous arthropathies
Key Points ■ Localized arthritis can be caused by metastatic disease, cartilaginous tumors, foreign body synovitis, synovial osteochondromatosis, pigmented villonodular synovitis, and palindromic rheumatism. ■ Polyarthritis can be caused by carcinomatous polyarthritis, bypass arthritis, hypertrophic osteoarthropathy, intermittent hydrarthrosis, multicentric reticulohistiocytosis,…
Digital clubbing and hypertrophic osteoarthropathy
Key Points ■ Hypertrophic osteoarthropathy is a syndrome characterized by abnormal proliferation of the skin and osseous tissues at the distal parts of the extremities. ■ Three features are typically present: a peculiar bulbous deformity of the tips of the…
Gaucher disease
Key Points ■ Gaucher disease (GD) results from the accumulation of glucosylceramide in organs and tissues throughout the body in characteristic storage cells, namely “Gaucher cells,” which are transformed macrophages. ■ The disease is caused by mutations in the β-glucocerebrosidase…
Hemochromatosis
Key Points ■ An arthropathy, chondrocalcinosis, and osteoporosis are complications of hereditary hemochromatosis (HH). ■ The hemochromatosis arthropathy usually mimics osteoarthritis. It is a common finding as it affects up to 25% of patients. MCPs 2,3 and ankle involvement is…