Plotkin's Vaccines

Vaccines to Prevent Mpox

INTRODUCTION Mpox (formerly monkeypox) is a disease caused by infection with the Monkeypox virus (MPXV), a zoonotic orthopoxvirus (OPXV) in the same genus as Variola virus (which causes smallpox). There are two distinct genetic clades, Clade I (formerly Congo Basin…

Ethics

The global effort to develop and deliver vaccines against COVID-19 has brought unprecedented attention and scrutiny to all aspects of vaccines and vaccination efforts, including the many ethical issues they raise. During public health emergencies and ongoing disease prevention efforts…

Legal Issues

This chapter reviews liability for vaccine injuries historically; the rationale, development, and implementation of the National Vaccine Injury Compensation Program (VICP); the VICP’s current status; and the CDC COVID-19 Vaccination Program; international vaccine compensation programs; and the power to compel…

Vaccine Safety

During the past 100 years, pharmaceutical companies have made vaccines against diphtheria, tetanus, pertussis, polio, measles, mumps, rubella, varicella, hepatitis A, hepatitis B, Haemophilus influenzae type B (Hib), pneumococcus, meningococcus, rotavirus, and human papillomavirus, among others ( Table 83.1 )…

Regulation of Vaccines in Low- and Middle-Income Countries

The World Health Organization (WHO) supports member states in strengthening their regulatory systems by setting norms and standards, promoting smart regulation, identifying strengths and gaps, providing specialized technical assistance, and capacity-building opportunities and advising on quality assurance of medicines for…

Regulation of Vaccines in Europe

## Vaccines are complex biological medicinal products developed using increasingly varied and/or novel sophisticated technologies. They can contain live or attenuated infectious agents, recombinant pathogen proteins, and other types of components, such as adjuvants. Because of the major individual and…

Regulation and Testing of Vaccines in the US

## Vaccines are one of the most significant achievements of science and public health. As a result of successful vaccination programs and campaigns, many vaccine-preventable diseases are now uncommon in the United States. Vaccines for the prevention of infectious diseases…

Economic Analyses of Vaccine Policies

At the time of writing this chapter, COVID-19 is the pandemic of the century, globally affecting macro and micro-economies. Recognition of the economic disruption from outbreaks on the regional level (Ebola viral disease) and global level (COVID-19) has led to…