Introduction Mood disorders are a common development in cases of traumatic brain injury (TBI). A number of factors contribute to the outcome of this phenomenon. For instance, factors preceding the trauma (eg, personal medical history, genetic vulnerability), characteristics of the…
Docosahexaenoic Acid and Omega 3 Fatty Acids Administration of omega 3 polyunsaturated fatty acids (n-3 PUFAs) is a biologically plausible, yet clinically untested, candidate therapeutic strategy to prevent or blunt neurologic disability after traumatic brain injury (TBI). The biologic plausibility…
Introduction Traumatic Brain Injury: Prevalence, Affected Population, and Sequelae Traumatic brain injury (TBI) is a noncongenital injury arising from blunt or penetrating injury to the head or from acceleration/deceleration forces. TBI is an important public health problem; an estimated of…
Introduction Excitotoxicity is known to contribute to neuropathology in acute neurological insults such as traumatic brain injury (TBI) and stroke, as well as chronic and insidious neurodegenerative disorders such as dementia of the Alzheimer’s type (AD). Although experimental models have…
Traumatic Brain Injury and Glutamate Excitotoxicity Traumatic brain injury (TBI) is among the most common causes of morbidity and mortality in the USA across all age groups ( ). Beyond the mechanical injury, TBI triggers a cascade of biochemical events…
Introduction Approximately 350,000 individuals in the United States are affected annually by severe and moderate traumatic brain injuries (TBIs) that may result in long-term disability. This rate of injury has produced over 3 million disabled citizens in the United States…
Acknowledgments This work was partially supported by grants from the National Institute of Neurological Disorders and Stroke (NINDS) including 5R01 NS083405 and 5R01 NS084857 and 5T32 NS077889 and with funds from the Kentucky Spinal Cord & Head Injury Research Trust.…
Leukotrienes The 5-lipoxygenase (5-LO) pathway mediates the production of leukotrienes, a class of potent inflammatory lipid mediators made in leuko cytes that contain a conjugated triene as part of their structure. The biosynthesis of leukotrienes is under strict control (for…
Traumatic Brain Injury The most recent reports from the Centers for Disease control estimate that over 3.2 million individuals experience a traumatic brain injury (TBI) annually in the United States, with well over 5.3 million patients reporting injury-induced chronic disability…
Acknowledgments We wish to acknowledge the expert operators of the LFP model system and TBI assays, Drs. Ahmar Ayub, Betul Cam, Huadong Zeng, and Thian Ng. Thanks go to Dr. Candace Floyd of the UAB Physical Medicine and Rehabilitation Department…