Neuropathology: High-Yield Pathology

Malformations

Neural Tube Defects Definition Failure in the proper closure of part or all of the neural tube; called induction disorder (neural tube induced by the notochord and paraxial mesoderm during the third to fourth week of gestation) Clinical Features Epidemiology…

Herniations

Definition Displacement of brain tissue from one intracranial compartment to another; these compartments are separated by rigid structures such as dura or bone Clinical Features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…

Hydrocephalus

Definition Buildup of cerebrospinal fluid (CSF) within the ventricles leading to brain swelling, increased intracranial pressure, and damage to brain tissue; most often caused by obstruction of CSF flow at common sites of obstruction: foramina of Monro, Luschka, and Magendie;…

Cerebral Edema

Definition Excess fluid accumulation within the brain parenchyma Brain, blood, and cerebrospinal fluid (CSF) exist in rigid compartments of skull and dura, leaving limited room for parenchymal expansion Cerebral edema results in increased intracranial pressure (ICP) Two principal types of…