1 Brain metastasis a. General approach i. Chapter 14 , Case 1: Approach to large, symptomatic brain metastasis—surgery ii. Chapter 14 , Case 2: Approach to innumerable multifocal brain metastasis—whole brain radiation iii. Chapter 14 , Case 3: Approach to…
1 Chapter 1 : Fundamentals of neuropathology: introduction to neuropathology and molecular diagnostics a. Classification of glioblastoma i. Microvascular proliferation and pseudopalisading necrosis are pathologic hallmarks of glioblastoma (GBM) and, when present, establish the diagnosis of GBM. ii. IDH1/2 gene…
Introduction Immune-based therapies have revolutionized cancer treatment. These agents enhance the immune system’s ability to seek out and attack tumor cells. One such treatment, CAR T-cells or chimeric antigen receptor T-cells, are a type of adoptive cell transfer therapy where…
Brief introduction to immunotherapy Immune-based therapies have emerged as a promising modality in cancer treatment. These therapies use the body’s immune system to fight cancer by harnessing the antitumor properties of the host immune system to eliminate the cancer. Several…
Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common side effects of cytotoxic chemotherapy and presents as a distal, symmetric polyneuropathy ( Table 28.1 ). Rates of CIPN depend on the agent being used but tend to occur…
Introduction With significant advances in cancer treatment, both the number of long-term cancer survivors and the complications to which these patients are vulnerable have grown. These complications can involve the peripheral and/or central nervous systems, significantly impairing quality of life…
Introduction Cranial irradiation is used in settings ranging from definitive treatment of primary brain and head and neck cancers to palliation of metastatic disease and prophylaxis, as a single modality or in combination with surgery or systemic therapy. Common side-effect…
Introduction Cognitive abilities in glioma patients are influenced by a myriad of factors: the tumor itself, depression and anxiety, fatigue, sleep dysfunction, pre–brain tumor cognitive baseline (e.g., premorbid functioning), pain, and brain tumor treatments themselves (e.g., surgery, chemotherapy, and radiation).…
Introduction Cerebral radiation necrosis is a challenging and potentially devastating complication of cranial irradiation. Based on the temporal relationship to radiation therapy (RT), it can be classified as pseudoprogression (a form of early subacute injury) or radiation necrosis (a form…
Acknowledgments We thank Dr. Andrew McKeon (Departments of Laboratory Medicine and Pathology and Neurology, Mayo Clinic, Rochester, Minnesota) for providing Case 23.6: Paraneoplastic neurological syndrome. Introduction Malignant cells of both B-cell and T-cell origin have a predilection for infiltrating into…