Pancreatic neuroendocrine tumors (PNETs), also known as “islet cell tumors,” represent a group of rare neoplasms of the neuroendocrine cells of the gastropancreatic system ( Fig. 132.1 ). PNETs constitute fewer than 5% of the pancreatic tumors. They may be…
The increasing use of abdominal imaging studies such as abdominal ultrasound, computed tomography (CT) scan, and magnetic resonance imaging (MRI) has contributed to the incidental detection of pancreatic cysts, some of which may be malignant and others premalignant or benign.…
Clinical Picture Globally, pancreatic cancer causes more than 331,000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. In the United States, pancreatic cancer is the fifth leading cause of cancer mortality. In…
Disease Forms and Clinical Picture The cardinal manifestations of chronic pancreatitis (CP) are recurrent or persistent abdominal pain that lasts for months to years, accompanied by diabetes, steatorrhea, and pancreatic calculi. Morphologically, the disease is characterized by destruction and loss…
Etiology and Clinical Picture Acute pancreatitis (AP), an inflammatory disorder of the pancreas characterized clinically by abdominal pain and biochemically by elevated levels of serum amylase and lipase, may present as a mild, self-remitting disorder or as a fulminant disease…
Cystic fibrosis (CF) is a progressive genetic disease transmitted by an autosomal recessive mechanism. Among Caucasians, the frequency is 1 in 2000 to 3000 live births but much less in African Americans (1 : 15,000) and Asian Americans (1 : 30,000). The carrier rate…
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Trichinosis The most common Trichinella species in the United States is Trichinella spiralis, which is almost worldwide in its distribution. However, other Trichinella species infect humans in Africa and in the arctic regions. Humans become infected by eating undercooked pork…