Skeletal muscle undergoes many changes in response to disease and trauma. With the electron microscope, the abnormalities seen at the light level can be characterized and accurately localized, and the variety of changes affecting each organelle identified. The interpretation of…
This chapter deals with the various changes that may occur in a muscle under pathological conditions. As we show, very few abnormalities are in themselves pathognomonic of a particular disease. However, by evaluating the constellation of different changes that are…
In this chapter, the composition and appearance of normal muscle will be discussed. The first part will be concerned with the anatomical constituents of normal muscle at the light microscope level, followed by histochemical aspects of the different types of…
Just as every pathologist has particular preferences for routine stains, so muscle histochemists have tended to develop preferences for particular reactions, especially in the interpretation of fibre types. In the early days of the application of histochemical techniques to the…
The Evolving Role of Muscle Pathology Muscle biopsy has been an important part of the assessment of patients with a neuromuscular disorder for many decades. The use of frozen sections and the application of histochemistry and electron microscopy have identified…