Meyler's Side Effects of Drugs

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General information Cinchocaine (dibucaine) is an aminoamide local anesthetic. It is ten times more potent than lidocaine and potentially very toxic. It is available in a number of over-the-counter topical formulations, such as antihemorrhoidal drugs. Organs and systems You’re Reading…

See also Anticholinergic drugs General information Cimetropium bromide is an anticholinergic drug that belongs to a series of scopolamine quaternary salts with antimuscarinic effects [ ]. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy…

See also Histamine H 2 receptor antagonists General information Cimetidine is a histamine H 2 receptor antagonist. General adverse effects and adverse reactions The main varieties of adverse effects attributed to cimetidine relate to its antiandrogenic properties and its actions…

General information Cilostazol is a phosphodiesterase inhibitor that suppresses platelet aggregation and also acts as a direct arterial vasodilator. Small studies in Japan suggested that it might be useful for treating chronic arterial disease and symptoms of intermittent claudication. A…

See also Phosphodiesterase type IV inhibitors General information Cilomilast is an orally active, potent, selective inhibitor of phosphodiesterase type IV, which was developed for the treatment of chronic obstructive pulmonary disease (COPD). However, a review of its efficacy and safety…

See also Angiotensin-converting enzyme inhibitors General information Cilazapril is a non-sulfhydryl ACE inhibitor [ ]. Like enalapril and ramipril it is a prodrug and is hydrolysed after absorption to cilazaprilat, which has a long half-life allowing once-daily administration [ ].…

General information Cidofovir ( S -1-3-hydroxy-2-phosphonylmethoxypropylcytosine), also known as HPMPC, is a nucleotide analogue with potent activity against cytomegalovirus (CMV) in vitro and in vivo. Drug studies Observational studies Cidofovir has been used to treat 14 patients with cytomegalovirus infection…

General information Ciclosporin is an immunosuppressant drug that primarily inhibits T cell activation, therefore down-regulating the T cell responses that mediate graft rejection. Myelotoxic effects are therefore not expected. Ciclosporin has also been used in a wide range of chronic…

General information Ciclesonide, a non-halogenated glucocorticoid, is converted locally in the airways to an active metabolite, desisobutyrylciclesonide, which has a 100-fold greater relative glucocorticoid receptor binding affinity than ciclesonide itself [ ]. The pharmacokinetic–pharmacodynamic profile of inhaled ciclesonide suggests a…