See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Cloximate is an oxime ether derivative non-steroidal anti-inflammatory drug (NSAID) [ ]. It was approved in only a few countries, and experience with it is limited. The usual adverse effects of NSAIDs…
See also Neuroleptic drugs General information Clotiapine is a dibenzothiazepine neuroleptic drug [ ]. Organs and systems You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member.…
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General information Clopidogrel is a thienopyridine compound, structurally related to ticlopidine, which inhibits ADP-induced platelet aggregation [ ]. Its efficacy in stroke, myocardial infarction, and other vascular causes of death has been demonstrated in the CAPRIE Study [ ], a…
General information The presynaptic α-adrenoceptor agonists, particularly methyldopa and clonidine, are agonists at presynaptic α 2 -adrenoceptors. Guanabenz, guanfacine, and tiamenidine appear to be qualitatively similar to clonidine; clear evidence of quantitative differences remains to be confirmed. The mechanism of…
General information Clonazepam is a benzodiazepine that is used predominantly in epilepsy, panic disorder, and mania, and also appears to be effective in relieving antipsychotic drug-induced akathisia [ ]. The use of clonazepam in psychiatric disorders is complicated by significant…
See also Tricyclic antidepressants General information Clomipramine is the imipramine analogue of chlorpromazine. However, while the difference between chlorpromazine and promazine is large, adding a chloride atom to imipramine hardly affects its actions. Most trials have failed to show any…
General information Clomiphene is a very weak non-steroidal estrogen; it blocks the feedback effect of endogenous estrogens on the pituitary, promoting the further secretion of gonadotropins. The primary use of clomiphene in women is in the induction of ovulation. In…
General information Clomethiazole is a sedative-hypnotic that has been used extensively in the treatment of alcohol withdrawal, as well as for inducing sedation and sleep in the elderly. In addition to GABA enhancement, which it shares with the benzodiazepines, clomethiazole…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information The NSAID clometacin is an indometacin derivative. Because of the risk of long-term or repeated use of clometacin, the French authorities restricted its use to prescriptions for no more than 8 days.…