General information Aldosterone is the principal physiological salt-retaining mineralocorticoid, but it is unsuitable for routine medical use since it is rapidly inactivated when given orally. Desoxycorticosterone (DCA, DOCA, desoxycortone) was used for a long time, but it had to be…
General information The local adverse effects of topical glucocorticoids [ , ] are listed in Table 1 . They include transient local erythema, calcinosis cutis, cramps (due to injection of crystals into a vessel), amaurosis (a dubious report), depigmentation, skin…
General information Eye-drops Glucocorticoids that have been used for local ophthalmic treatment as eye-drops include medrysone, fluorometholone, tetrahydroxytriamcinolone, and clobetasone. Loteprednol etabonate 0.5% increases intraocular pressure less than dexamethasone. Studies on animal models of uveitis and two randomized double-masked trials…
General information The safety of nasal glucocorticoids in the treatment of allergic rhinitis has been reviewed [ , ]. The local application of glucocorticoids for seasonal or perennial rhinitis often results in systemic adverse effects. The use of nasal sprays…
General information Intralesional triamcinolone acetonide has been used extensively for the treatment of hypertrophic and keloid scars. Complications are few, usually being local skin color changes, prominent vascular markings, or subcutaneous atrophy. You’re Reading a Preview Become a Clinical Tree…
General information Local injections of glucocorticoids into and around the joints can have a dramatic therapeutic effect, but the catabolic effect can have serious consequences, including adverse effects on joint structure [ ] and on local tendons, subcutaneous atrophy, and…
See also Inhaler propellants General information Treatment with inhaled glucocorticoids reduces the need for oral glucocorticoids in the treatment of severe asthma. The compounds used for inhalation have high local activity and low systemic availability when delivered to the lung.…
General information Epidural The indications, rationale, techniques, alternatives, contraindications, complications, and efficacy of lumbar and caudal epidural glucocorticoid injections have been reviewed [ ]. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles…
General information Nomenclature The two main classes of adrenal corticosteroids are properly known as glucocorticoids and mineralocorticosteroids. The former are often known by shorter names and are commonly referred to as “glucocorticoids”, “corticosteroids”, “corticoids”, or even simply “steroids”; the latter…
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