See also Cytotoxic and immunosuppressant drugs General information Dacarbazine is converted to an active metabolite that is thought to be an alkylating agent. It has been used to treat metastatic melanoma and, in combination regimens, soft-tissue sarcomas and Hodgkin’s disease.…
General information Dabigatran etexilate is a prodrug of dabigatran, a specific, competitive, reversible inhibitor of thrombin. Dabigatran etexilate is rapidly absorbed after oral administration and converted to dabigatran. Its half-life is about 8 hours after a single dose and 14–17…
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See also Alkylating cytostatic agents—nitrosoureas and N -lost derivatives ; Platinum-containing cytostatic drugs General information Cytotoxic drugs generally have both anticancer and immunosuppressive properties, while immunosuppressant drugs have more specific immunosuppressive effects, although this is a somewhat arbitrary distinction. Monoclonal…
See also Cytotoxic and immunosuppressant drugs General information Cytarabine is a pyrimidine nucleoside that is used to treat acute myelogenous leukemia and lymphocytic leukemias. It is activated intracellularly by deoxycytidine kinase to phosphorylated nucleotides that interfere with DNA synthesis in…
See also Antihistamines General information Cyproheptadine is a first-generation antihistamine with antiserotoninergic effects [ ]. It has been used because of its appetite-stimulating capacity. Drowsiness and other adverse effects common to the first-generation antihistamines are common. Organs and systems Nervous…
See also Antituberculosis drugs General information Cycloserine is an aminoisoxazolidone that shows no cross-resistance with other tuberculostatic agents [ ]. Because of its high toxicity, it should only be used when micro-organisms are resistant to other drugs (relapse or primary…
See also Anesthetics, general General information Cyclopropane is an inhalational anesthetic gas. Its minimum alveolar concentration (MAC) is 9.2%. Because of the risk of explosion, it is usually administered by closed circuit [ ]. Organs and systems You’re Reading a…
General information Cyclophosphamide is an alkylating nitrogen mustard derivative mainly used in oncology patients [ ] or in conditioning regimens for bone marrow transplantation. Its immunosuppressant properties have been used in organ transplantation and more often in chronic inflammatory disorders…
See also Anticholinergic drugs General information Cyclopentolate is an anticholinergic drug used in eye-drops as a mydriatic. It can cause both local [ ] and systemic adverse reactions [ , ]. Organs and systems Nervous system Seizures have occasionally been…