General information Decamethonium, a depolarizing neuromuscular blocker, is little used nowadays. A dose of 3 mg provides adequate relaxation for intra-abdominal surgery for about 15 minutes, supplements being required at intervals of 10–30 minutes. It is not as rapid in…
General information Dasatinib (BMS-354825), a thiazole carboximide derivative, is structurally related to imatinib. It targets src kinase and imatinib-resistant bcr–abl kinase and has impressive activity in patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia [ , ].…
General information Daptomycin is a novel lipopeptide antibiotic, an inhibitor of lipoteichoic acid synthesis, with potent bactericidal activity against most clinically important Gram-positive bacteria, including resistant strains [ , ], such as meticillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci and was…
General information Dapsone is 4,4-diaminodiphenylsulfone (DDS, avlosulfone, disulfone) [ ]. It is a bacteriostatic antileprosy drug with a sulfonamide-like structure. The dosage should be 50–100 mg/day in adults [ ]. In children aged 3–5 years, the dosage should be reduced…
General information Dantrolene, a hydantoin derivative, is well established in clinical practice, being of greatest value for the reduction of clonus and involuntary muscle spasms [ , ]. The recommended oral doses for the treatment of spastic conditions are 75–400…
General information Danazol is a weak androgen and can thus exert the adverse effects of androgens, but because it inhibits LH and FSH secretion it can also elicit menopausal-like symptoms. However, from time to time it has other types of…
General information Danaparoid is a low molecular heparinoid consisting of a mixture of sulfated glycosaminoglycans (heparan, dermatan, and chondroitin sulfates). It has an antithrombotic effect via antithrombin III-mediated inhibition of factor Xa and to a lesser extent through inhibition of…
General information Dalbavancin (BI 397) is a semi-synthetic derivative of A40926, a glycopeptide with a structure related to that of teicoplanin [ , ]. Dalbavancin is more active against Streptococcus pneumoniae than conventional glycopeptides are, and its activity against Staphylococcus…
See also Cytotoxic and immunosuppressant drugs General information Dactinomycin (actinomycin D) is used to treat cancers in children, in particular Wilms’ tumor. It has similar adverse effects to doxorubicin. You’re Reading a Preview Become a Clinical Tree membership for Full…
See also Monoclonal antibodies General information Daclizumab, a humanized antibody directed against the alfa chain of the interleukin-2 receptor, has been used for initial immunosuppression in transplant patients. In a phase III trial in 275 patients who received ciclosporin, glucocorticoids,…