See also Antihistamines General information Desloratadine is the primary metabolite of loratadine, with superior H1 receptor binding, potent antihistaminic activity compared with the parent compound, and proven efficacy in allergic disease [ ]. It is effective and well tolerated in…
See also Anesthetics, general General information Desflurane is identical in structure to isoflurane, except that it is halogenated completely with fluorine instead of fluorine and chlorine. Desflurane is a volatile anesthetic that combines low blood gas solubility with moderate potency…
General information Deoxyspergualin is a synthetic analogue of the immunosuppressive anti-tumor antibiotic spergualin. It contains the polyamine spermidine as part of its structure and has similar properties and mechanisms of action to ciclosporin and the calcineurin inhibitors. It has been…
General information Denileukin diftitox is a genetically engineered fusion protein combining the enzymatically active domains of diphtheria toxin and the full-length sequence for interleukin-2 (IL-2). It targets lymphoma cells that express the high-affinity IL-2 receptor. In vitro, the retinoid X…
See also Non-nucleoside reverse transcriptase inhibitors (NNRTIs) General information Delavirdine is a non-nucleoside reverse transcriptase inhibitor, which is dosed three times daily. No food restrictions apply. It is metabolized mainly by CYP3A, and so interactions with other drugs that use…
General information Defibrotide is a polydeoxyribonucleotide extracted from mammalian organ [ ]. Its antithrombotic activity is partly ascribed to enhancement of eicosanoid metabolism, in particular increased release of prostacyclin, with ensuing vasodilatation and inhibition of platelet aggregation. An additional mechanism…
General information Deferoxamine is a polyhydroxamine acid with specific affinity for iron and, less strongly, aluminium. It is a naturally occurring siderophore produced by Streptomyces pilosus. Uses Deferoxamine is used in the treatment of acute iron poisoning and in iron…
General information Deferiprone is an alpha-ketohydroxypyridine compound with metal-chelating properties [ ]. It is absorbed within minutes after oral administration and reaches maximum blood concentrations within 1 hour. It has a half-life of 1–2 hours, and is almost completely undetectable…
General information Deferasirox (ICL670), a hydroxyphenyltriazole derivative, is a tridentate selective iron chelator and an N-substituted bis-hydroxyphenyltriazole compound for oral use, available as 125, 250, and 500 mg tablets and administered in a daily dose of 20–50 mg It is…
General information Decitabine (5-aza-2′-deoxycytidine) is structurally very similar to azacitidine [ ]. Both drugs have promising activity against acute myeloblastic leukemia and myelodysplastic syndrome. In addition, decitabine has significant activity against chronic myeloid leukemia. It is rapidly metabolized in the…