General information Dibenzepin is a 6,7,6 tricyclic compound of the dibenzodiazepine type. A comparison with imipramine was said to show equal efficacy; adverse reactions were comparable in type and degree [ ]. You’re Reading a Preview Become a Clinical Tree…
General information Diazoxide is a direct vasodilator that acts on vascular smooth muscle to produce systemic vasodilatation. As a result there is baroreceptor-mediated activation of the sympathetic nervous system and the renin–angiotensin system. Vasodilators (as monotherapy) are associated acutely with…
General information Diazepam produces less sedation in cigarette smokers, and higher doses may be required for the same sedative or anxiolytic effect. Owing in part to its continued widespread use, several unusual adverse effects of diazepam continue to be reported.…
General information Heroin is a potent opioid that offers no substantial advantages over morphine. In the UK it is the preferred parenteral opioid for subcutaneous administration to cachectic cancer patients, because of its high solubility. The prevalence of heroin as…
General information Diaminopyridine (3,4-diaminopyridine), now also known as amifampridine, blocks calcium-dependent potassium channels and prolongs the duration of the action potential at motor nerve terminals; this enhances calcium influx into nerve endings and causes release of acetylcholine [ ]. It…
General information Dialysis fluids are solutions of electrolytes formulated in concentrations similar to those of extracellular fluid or plasma. They contain, or may contain: sodium; chloride; bicarbonate or lactate; calcium; magnesium; potassium; glucose; amino acids; icodextrin. Dialysis fluids are provided…
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General information The most frequent adverse reactions to dextropropoxyphene are dizziness, sedation, and nausea and vomiting. Other reported reactions include constipation, abdominal pain, skin rashes, light-headedness, headache, weakness, euphoria, dysphoria, minor reversible visual disturbances, and liver dysfunction [ ]. A…
General information Dextromethorphan is the dextrorotatory isomer of the synthetic opioid levorphanol [ ]. It is a non-competitive antagonist at N -methyl- d -aspartate (NMDA) receptors. It also binds to CNS sigma opioid binding sites [2] and increases 5-HT concentrations…