See also Cytotoxic and immunosuppressant drugs General information Hydroxycarbamide (hydroxyurea) is used to treat a variety of cancers, myeloproliferative disorders, and sickle cell disease, and has been studied in patients with HIV infection [ ]. It inhibits ribonucleotide reductase and…
General information Hydroquinone has been used in skin bleaching formulations for the treatment of hyperpigmentation and can cause short- and mid-term reactions like exogenous ochronosis and leukoderma en confetti, irritant reactions, and allergic reactions [ ]. Long-term adverse reactions such…
General information Intolerable adverse reactions or inadequate analgesia occur in 10–15% of patients with chronic pain given continuous intrathecal morphine. Hydromorphone is a semisynthetic derivative of morphine used extensively in the management of cancer pain. It is more soluble than…
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See also Fluoride salts and derivatives General information Hydrofluoric acid is widely used in industrial settings, but also in domestic products, such as cleaning solutions and rust removers. On the other hand, it is one of the most corrosive inorganic…
General information Hydrocodone is a semisynthetic narcotic analgesic and a cough suppressant, similar to codeine. It is metabolized to the O- and N-demethylated products, hydromorphone and norhydrocodone [ ]. Drug studies You’re Reading a Preview Become a Clinical Tree membership…
General information Hydrazine sulfate has been claimed to be effective in the management of cancers [ , ] and has been promoted as an alternative cancer cure [ ]. However, double-blind, randomized, placebo-controlled studies have suggested no benefit from hydrazine…
General information Hydralazine is a direct vasodilator that acts on vascular smooth muscle to produce systemic vasodilatation. As a result there is baroreceptor-mediated activation of the sympathetic nervous system and the renin–angiotensin system. Vasodilators (as monotherapy) are associated acutely with…
General information Hycanthone is a derivative of lucanthone, but has less gastrointestinal and nervous system toxicity. It is effective against both Schistosoma hematobium and Schistosoma mansoni and is given as a single intramuscular injection in doses of 1.0–2.5 mg/kg […
General information Hyaluronidase is an enzyme that depolymerizes the mucopolysaccharide hyaluronic acid, which is a component of the mucoprotein ground substance or tissue cement and thus increases membrane permeability, reduces viscosity, and makes tissues more readily permeable [ ]. It…