See also Cytotoxic and immunosuppressant drugs General information Ifosfamide is an alkylating agent belonging to the group of oxazaphosphorines. It is used to treat a variety of solid tumors in children, including rhabdomyosarcoma, soft tissue sarcomas, Wilms’ tumor, bone sarcomas,…
General information Idoxuridine, which is active against Herpes simplex and Varicella zoster , has only been used in topical antiherpetic solutions. It has been used to treat superficial keratitis, but with poor results in deep stromal diseases because of poor…
General information Like tamoxifen, toremifene, and droloxifene, idoxifene is a polyphenylethylene antiestrogen. It is a selective estrogen receptor modulator (SERM) with greater antiestrogenic activity than tamoxifen but less estrogenic activity. Its preclinical toxicology has been reviewed [ ]. You’re Reading…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) GENERAL INFORMATION Ibuproxam (2-(4-isobutylphenyl)-propiohydroxamic acid) is a derivative of ibuprofen (2-(4-isobutylphenyl)-propionic acid), and after absorption is gradually hydrolysed to ibuprofen [ ]. It is supposed to be less gastrotoxic than ibuprofen. However, gastrointestinal adverse…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Like other non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen is a potent inhibitor of prostaglandin synthesis, and many or all of its therapeutic and toxic effects are linked to this characteristic. The general impression…
See also Monoclonal antibodies General information Ibritumomab is a murine IgG 1 anti-CD20 antibody, the parent of the engineered chimeric antibody rituximab, a monoclonal antibody with mouse variable and human constant regions. It induces apoptosis and has antiproliferative effects. Ibritumomab…
General information Ibopamine is a dopamine derivative that has been studied in patients with congestive heart failure [ ] and has been used as a preoperative mydriatic for cataract surgery [ ] and to treat chronic refractory ocular hyptotony, although…
See also Anticholinergic drugs General information Hyoscine is an anticholinergic drug, a stereoisomer of atropine. It is available in different salts, hyoscine hydrobromide and hyoscine butylbromide. When given parenterally hyoscine butylbromide is effective but very short-acting; when given by mouth…
See also Antivenoms , Immunotherapy General information The Hymenoptera genus, one of the largest genera of insects, includes bees and wasps, sawflies and ants. The name comes from Greek words for a membrane (hymen) and a wing (pteron). Bee and…
See also Antihistamines General information Hydroxyzine is a first-generation antihistamine, a piperazine derivative, with antimuscarinic and sedative properties. Organs and systems You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If…