See also Antifungal azoles [for systemic use] General information Itraconazole is a triazole antifungal drug. It is used orally to treat oropharyngeal and vulvovaginal candidiasis, pityriasis versicolor, dermatophytoses unresponsive to topical treatment, and systemic infections, including aspergillosis, blastomycosis, chromoblastomycosis, coccidioidomycosis,…
See also Calcium channel blockers General information Isradipine is a dihydropyridine calcium channel blocker. Drug studies Comparative studies The MIDAS study [ ] was a randomized trial of isradipine versus hydrochlorothiazide over 3 years in 883 patients, designed primarily to…
See also Adrenoceptor agonists General information Isoxsuprine is a beta 2 -adrenoceptor agonist that also has antagonist action at alpha-adrenoceptors. It has been variously described as a beta-agonist, a specific vasorelaxant, a uterine relaxant, and an agent that reduces blood…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information The oxicam NSAID isoxicam has a shorter half-life (30 hours) than piroxicam. However, there are large variations in half-life, clearance, and mean steady-state plasma concentrations. Except for edema, the incidence of adverse…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Isoxepac has been used as an analgesic after joint surgery [ ] and in the management of rheumatoid arthritis [ ] and dysmenorrhea [ ]. You’re Reading a Preview Become a Clinical…
General information Isopropanolamine is used in cosmetics, hair perms, hair sprays, and in tanning lotions as a buffering agent. Derivatives of isopropanolamine have been developed as HIV protease inhibitors [ , ]. Occupational exposure to monoisopropanolamine can irritate the upper…
See also Anticholinergic drugs General information A 5–10 mg oral dose of the anticholinergic drug isopropamide iodide produces typical anticholinergic effects and has been used to treat a range of disorders of the gastrointestinal tract [ , ] and urinary…
See also Adrenoceptor agonists General information As a non-selective beta-adrenoceptor agonist, isoprenaline produces a wide range of adrenergic effects. Those that involve the heart present the most marked problems in practice. Doses of up to 10 micrograms/minute are used to…
See also Antituberculosis drugs General information Isoniazid is the hydrazide of isonicotinic acid. It is a first-line drug for treatment and prevention of tuberculosis. It is bactericidal for rapidly dividing mycobacteria, but bacteriostatic for “resting bacilli”. Among non-tuberculosis mycobacteria, only…
General information Isometheptene is an indirect sympathomimetic with a tyramine-like action and is also an agonist at alpha-adrenoceptors. It has been used as a non-prescription drug in the treatment of migraine [ , ], often in combination with other analgesics…