See also Antiepileptic drugs . General information Levetiracetam is a piracetam derivative used in the treatment of refractory partial seizures. In trials it has shown an excellent tolerability profile. The main dose-related adverse reactions are sedation, fatigue, and headache. Other…
General information Levamisole is the levorotatory isomer of tetramisole. Originally used only as an antihelminthic drug, it acts by paralysing the musculature of susceptible nematodes so that they are expelled by peristalsis. It is rapidly metabolized and excreted, with a…
General information The leukotriene receptor antagonists are antagonists of cysteinyl leukotrienes at CysLT 1 receptors and include zafirlukast, montelukast, and pranlukast. Drug studies Placebo-controlled studies The efficacy and tolerability of montelukast, in combination with a selective histamine H 1 receptor…
General information Letosteine is a mucolytic, used orally to loosen bronchial secretions and facilitate expectoration [ , ]. In a systematic review of six randomized controlled trials in 438 children, antitussives, antihistamine-decongestant combinations, other fixed drug combinations, and antihistamines were…
General information Lesopitron is a non-benzodiazepine anxiolytic drug. Its structure is similar to that of buspirone, and it is an agonist at central serotonin (5-HT 1A ) receptors [ ]. In a 6-week, double-blind, randomized, parallel, phase II, single-center, outpatient…
See also Calcium channel blockers General information Lercanidipine is a third-generation dihydropyridine for once-daily dosing in hypertension. It has similar antihypertensive efficacy and adverse effects to other calcium channel blockers [ ]. Drug studies You’re Reading a Preview Become a…
General information Lepirudin is a direct thrombin inhibitor obtained by recombinant technology from the medicinal leech and used for treatment of patients with heparin-induced thrombocytopenia and allergic reactions [ ]. An 85-year-old woman developed localized infiltrated plaques followed by a…
General information Lentinan is an immunomodulating glucan that is extracted from the mushroom Lentinus edodes. It has been used in small numbers of patients with gastric cancers [ ] and malignant effusions [ ]. It has also been used in…
See also Manitimus General information Teriflonumide (A77 1726) is the active metabolite of the prodrug leflunomide ( N -(4′-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide), an isoxazole derivative. [ ]. Mechanism of action Teriflunomide inhibits dihydro-orotate dehydrogenase, the rate-limiting enzyme in pyrimidine synthesis. It inhibits the…
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