General information Racecadotril (ecadotril, anorphan, (S)-aetophan), through its active metabolite thiorphan, is an inhibitor of the neutral endopeptidase known as enkephalinase, thereby increasing exposure to substrates of the enzyme, including enkephalins and atrial natriuretic peptide [ ]. Increased exposure to…
See also Vaccines General information Rabies vaccine was for a long time prepared from infected brain tissue, and neurological complications were likely to occur in as many as one in 300 cases. A second-generation vaccine prepared from duck embryo tissue…
See also Proton pump inhibitors General information The benefit to harm balance of rabeprazole, a proton pump inhibitor, has been reviewed [ , ]. The overall rate of drug withdrawal because of adverse reactions was 3%. Common adverse reactions included…
General information Quinupristin and dalfopristin are two semisynthetic pristinamycin derivatives that are given in combination parenterally. Each component has bacteriostatic activity against Gram-positive bacteria, including multidrug resistant bacilli [ , ]. Quinupristin + dalfopristin can be used to treat macrolide-resistant…
General information Quinine was originally extracted from the bark of the Cinchona tree (Peruvian bark or Jesuits’ bark) and was used to treat ague (i.e. fever), usually due to malaria. It fell out of fashion with the advent of other…
General information Quinidine is a class I antidysrhythmic drug. Its actions, clinical use, interactions, and adverse effects and reactions have been reviewed [ ]. General adverse effects and adverse reactions Gastrointestinal symptoms, including anorexia, nausea, and vomiting, are common. Quinidine…
General information Quinfamide is a dichloroacetyl quinolol that has been used as an amebicide [ ]. It acts on the trophozoites of Entamoeba histolytica , making the trophozoite incapable of propagation. It is not active against amebic cysts. In doses…
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See also Angiotensin-converting enzyme inhibitors General information The pharmacology, therapeutic uses, and safety of the ACE inhibitor quinapril have been reviewed [ ]. Organs and systems You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy…
General information Quinagolide is a non-ergot benzoquinoline dopamine D 2 receptor agonist. It has mainly been used to treat hyperprolactinemia [ , ], and also in Parkinson’s disease [ ], ovarian hyperstimulation syndrome [ ], and to suppress lactation […