See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Data are insufficient to indicate whether the oxicam NSAID lornoxicam is safer for the gastrointestinal tract than other oxicam derivatives [ ]. Headache, dizziness, and gastrointestinal symptoms are the most frequent adverse…
See also Benzodiazepines General information Lormetazepam is a short-acting benzodiazepine with effects similar to those of diazepam. Drug studies You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are…
General information Lorenzo’s oil is a 4:1 mixture of glyceryl trioleate and glyceryl trierucate. It is used in patients with adrenoleukodystrophy. The dyslipidemia in patients with adrenoleukodystrophy consists of increased blood concentrations of very-long-chain saturated fatty acids, particularly hexacosaenoic acid…
See also Antidysrhythmic drugs General information The clinical pharmacology, clinical use, efficacy, and adverse effects of lorcainide have been reviewed [ ]. The adverse effects of lorcainide may be partly caused by its active metabolite, norlorcainide, which accumulates during treatment…
See also Benzodiazepines General information Lorazepam is a benzodiazepine with CNS, depressant, anxiolytic, and sedative properties, used as a hypnotic, sedative, and anxiolytic drug. Drug studies Comparative studies In a multicenter, randomized, double-blind comparison of diazepam (0.15 mg/kg followed by…
See also Antihistamines General information Loratadine is a second-generation antihistamine [ ]. Drug studies Placebo-controlled studies Adverse events (including dry mouth, headache, and insomnia) were reported in 30% of those taking loratadine + pseudoephedrine (5 + 120 mg bd for…
See also HIV protease inhibitors General information Lopinavir is a nucleoside analogue reverse transcriptase inhibitor, which is used in combination with ritonavir, another nucleoside analogue reverse transcriptase inhibitor, in the treatment of AIDS. The pharmacology, clinical pharmacology, uses, adverse effects,…
See also Opioid receptor agonists General information Loperamide is an opioid whose action is almost completely restricted to the gut. Recognition of its consequent safety, if it is appropriately used, has led to its being released in many countries for…
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See also Cytotoxic and immunosuppressant drugs General information Lometrexol is a folic acid analogue, 5,10-dideaza-5,6,7,8-tetrahydrofolic acid, which acts as an antifolate drug and targets de novo purine synthesis in tumor cells by inhibiting glycinamide ribonucleotide formyltransferase (GARFT), a folate-dependent enzyme…