See also Neuroleptic drugs General information Perphenazine is a phenothiazine neuroleptic drug. Drug studies You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
General information Benzoyl peroxide Benzoyl peroxide is an antimicrobial and keratolytic agent used in the treatment of acne; it is also added to some foods. It is a catalyst for cross-linking in the production of plastics and is occasionally used…
See also Angiotensin-converting enzyme inhibitors General information Perindopril is a prodrug ester of perindoprilat, an angiotensin converting enzyme (ACE) inhibitor that has been used in patients with hypertension and heart failure. An updated review of its use in hypertension has…
General information Perhexiline, 2-(2,2-dicyclohexylethyl)piperidine, was originally developed as an antianginal drug in the late 1960s [ ]. However, it caused severe serious adverse reactions, particularly a peripheral neuropathy and hepatotoxicity, in a small proportion of patients, particularly poor CYP2D6 metabolizers,…
General information Pergolide is a dopamine receptor agonist, who adverse effects and reactions resemble those of bromocriptine [ ]. Drug studies Observational studies In 41 patients with Parkinson’s disease who took pergolide, confusion and hallucinations were the adverse reactions that…
See also Hemoglobin-based oxygen-carrying blood substitutes; Ultrasound contrast agents General information Oxygen carriers can be divided into two classes: synthetic perfluorocarbons and hemoglobin-based oxygen carriers, prepared from hemoglobin of human or bovine origin (see separate monograph). It is important for…
General information Pentoxifylline (oxipentifylline) is a methylxanthine that antagonizes the vasoconstrictor effects of catecholamines and increases cyclic AMP concentrations, causing smooth muscle to relax. It has also been claimed to correct impaired microcirculation, by improving various factors that disturb blood…
General information Pentostatin (2′-deoxycoformycin) is a natural product isolated from Streptomyces antibioticus . It is a potent and irreversible inhibitor of adenosine deaminase, which is widely distributed in mammalian tissues, with particularly high constitutive activity in lymphocytes (T cells more…
General information Pentetrazol (pentylenetetrazol) is a central and respiratory stimulant, similar to doxapram hydrochloride. It is a GABA A receptor antagonist and is anxiogenic [ ]. It has been used in respiratory depression and has also been included in multi-ingredient…
General information Pentazocine is a partial agonist at opioid receptors. Adverse reactions to effective doses are largely typical of its class [ , ], with some quantitative exceptions. Drug studies Comparative studies Pentazocine and morphine were compared in 16 non-abusing…