General information Amylin is a peptide hormone produced in the beta-cells of the islets of Langerhans and co-secreted with insulin. It has glucoregulatory effects that may complement the actions of insulin. Pramlintide is an amyloid analogue [ ]. It is…
General information Amygdalin is a glycoside that was initially isolated from the seeds of the almond tree Prunus dulcis ; it is also found in Prunus amygdala (bitter almond) [ ], Prunus armeniaca (apricot), Prunus serotina (black cherry) [ ],…
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See also Phosphodiesterase type III inhibitors General information Amrinone is an inhibitor of phosphodiesterase type III, and has a positive inotropic effect. Its adverse effects [ ] include thrombocytopenia (10%), hypotension, tachydysrhythmias (sometimes resulting in syncope and death) (9%), worsening…
See also HIV protease inhibitors General information The marketing authorization of amprenavir (Agenerase) was withdrawn for commercial reasons at the request of the marketing authorization holder in 2011. Since fosamprenavir is still marketed and is a prodrug for amprenavir, adverse…
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General information Having a broad-spectrum fungicidal activity, amphotericin remains the mainstay of treatment of most invasive fungal infections. Compared with conventional amphotericin B deoxycholate, other lipid formulations of amphotericin (amphotericin B colloidal dispersion, amphotericin B lipid complex, and liposomal amphotericin…
General information Note on spelling In International Non-proprietary Names the digraph -ph- is usually replaced by -f-, although usage is not consistent, and -ph- is used at the beginnings of some drug names (for example, compare fenfluramine and phentermine) or…
See also Tricyclic antidepressants General information Amoxapine has a tricyclic nucleus with a modified piperazine side chain and is closely related to the neuroleptic drug loxapine [ ]. In animals, amoxapine has no antiserotonergic properties and less anticholinergic activity than…
General information Amopyroquine is a 4-aminoquinoline, structurally related to amodiaquine. It is not a new compound, but it is of renewed interest as a result of the extensive occurrence of resistance to chloroquine and the adverse effects of prophylactic amodiaquine.…