Massachusetts General Hospital Comprehensive Clinical Psychiatry

Serious Mental Illness

Key Points Five percent of adults in the US suffer from a serious mental illness (SMI), which is defined as a psychiatric illness that persists and is accompanied by functional disability. Modern, patient-centered treatment occurs in recovery-oriented community settings and…

Genetics and Psychiatry

Key Points Background Most psychiatric disorders have a genetic component. The etiology of psychiatric disorders reflects a combination of genetic vulnerability and environmental factors Many psychiatric disorders can be familial and heritable due to the inheritance of genetic variations. Alternatively,…

Statistics in Psychiatric Research

Key Points Three classes of statistics are used commonly in psychiatric research: psychometric statistics assessing the reliability and validity of diagnostic interviews or rating scales ; descriptive statistics used to describe a group of subjects on these clinical variables and…

Psychiatric Epidemiology

Key Points Epidemiology is the study of the distribution and determinants of disease frequency in humans to inform the natural history, service needs, and etiology of illness. The frequency of disease can be expressed in different concepts, including cumulative incidence,…

Psychiatric Aspects of HIV Infection and AIDS

Key Points Highly active antiretroviral therapy (HAART) has transformed infection with the human immunodeficiency virus (HIV) from a terminal illness to a chronic, treatable condition. Psychiatric and substance use disorders are frequent concomitants of HIV infection and complicate its diagnosis…