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Managing Treatment-Resistant Depression

Joined: May 16, 2024
Articles: 40

Psychiatric/Mental Health

Maintaining motivation and preserving the therapeutic alliance as tools to overcome treatment-resistant depression

Thus far, this text has focused on the understanding and application of a broad range of interventions to improve outcomes in treatment-resistant depression. Understanding the breadth of psychopharmacologic and psychotherapeutic interventions permits tailoring treatment to specific patient characteristics to ensure…

March 17, 2024

Psychiatric/Mental Health

Managing the risk of suicide in people with treatment-resistant depression

Introduction The management of suicide risk is often integral to the care of people with treatment-resistant depression (TRD). Suicide is a major public health concern worldwide, and yet it is a problem that remains poorly understood. Suicide occurs across a…

March 17, 2024

Psychiatric/Mental Health

Lifestyle interventions for treatment-resistant depression

Introduction There are several common circumstances in which treatments outside the traditional Western Allopathic medical tradition can be useful for patients with treatment-resistant depression (TRD). While many patients benefit only partially from maximized medication and psychotherapy and desire additional evidence-based…

March 17, 2024

Psychiatric/Mental Health

Treatment-resistant depression in pregnancy, the postpartum period, and transition to menopause

Introduction The lifetime risk for depression is greater in women than men ( ) and is especially high during female reproductive events including the perimenstrual, peripartum, and perimenopausal phases. The increased depression prevalence in women during reproductive transitions is hypothesized…

March 17, 2024

Psychiatric/Mental Health

Managing treatment resistant depression in primary care settings

Scope of problem Major Depressive Disorder (MDD) is a common, often recurrent or chronic illness associated with significant morbidity. According to the World Health Organization, an estimated 4.4% of the global population suffers from depression. MDD is among the five…

March 17, 2024

Psychiatric/Mental Health

Chronotherapeutics for treatment-resistant depression

Introduction According to the World Health Organization (WHO), bipolar or unipolar depression is the leading cause of ill health and disability worldwide. Depression affects nearly 20% of the population with an increase of more than 18% having been observed between…

March 17, 2024

Psychiatric/Mental Health

Drugs under investigation for treatment-resistant depression

Medications targeting the hypothalamic–pituitary–adrenal (HPA) axis Dysfunction in the hypothalamic–pituitary–adrenal (HPA) axis is one of the most well-established biological alterations in psychiatry ( ). The first observations of an elevation in basal cortisol levels in patients with depression were made…

March 17, 2024

Psychiatric/Mental Health

Inhaled gases for treatment-resistant major depression

Acknowledgment Special thanks to Britt Gott, MS, for her editorial input and assistance with the compilation of this chapter. Introduction Fortunately, most individuals who suffer from major depressive disorder (MDD) respond to first-line antidepressant treatments [pharmacotherapy and psychotherapy; ( ;…

March 17, 2024

Psychiatric/Mental Health

Managing treatment-resistant depression in the setting of chronic pain

Among the many challenges of treating depression are the complications that arise when the depression is concurrent with other medical conditions. Not surprisingly, when a patient has two conditions, insufficient treatment of one condition may worsen the presentation or treatment…

March 17, 2024

Psychiatric/Mental Health

Managing treatment-resistant depression with comorbid substance use disorders

Introduction Overview: Double-trouble Substance use disorders (SUDs) and depressive disorders, including major depressive disorder (MDD), dysthymia, and substance induced mood (depressive) disorder (SIMD) are among the most prevalent psychiatric disorders in the world ( ; ). Not only are both…

March 17, 2024