■ Introduction and Classification Expanding knowledge of acute myeloid leukemia (AML) over the past four decades has resulted in major advances in the understanding and classification of this disease. AML is known to represent a number of distinct but related…
■ Introduction The mature T-cell and natural killer (NK)-cell leukemias form a heterogeneous group of diseases with diverse etiologies and markedly varied clinical behavior. When applied to T cells, the term mature or peripheral is often used to describe nonblastic…
▪ Introduction The leukemias of mature B cells are a limited set of diseases in which blood and bone marrow are the primary sites of involvement. Although any lymphoproliferative disorder can eventually enter a leukemic phase, this chapter is limited…
▪ Introduction In this chapter we review the definition and current classification of Hodgkin lymphoma (HL), describe the histologic and immunohistochemical features, and discuss the differential diagnosis of this intriguing disease. HL has some unusual clinical, morphologic, and biological features…
■ Introduction Lymphoproliferative disorders are innately disorders of the immune system, and the immunodeficiency-related lymphoproliferative disorders are of particular interest because they offer a paradigm for studying the relationships between the immune system and the evolution of neoplastic disease. Although…
■ Introduction Peripheral T-cell lymphomas (PTCLs) are much less common than B-cell lymphomas, and they constitute approximately 10% of non-Hodgkin lymphomas (NHLs) in the United States and Europe. Derived from post-thymic T cells, PTCLs generally arise in lymphoid tissues ”peripheral”…
■ Introduction This chapter covers diffuse aggressive B-cell lymphomas in immunocompetent patients. In the 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms concepts regarding diffuse and aggressive B-cell lymphomas have been further revised to reflect the…
▪ Introduction This chapter covers the lymphomas of small B lymphocytes: small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL), mantle cell lymphoma (MCL), follicular lymphoma (FL), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT), splenic marginal zone lymphoma (SMZL), nodal marginal…
▪ Introduction A wide variety of benign conditions can be encountered in the bone marrow, and their clinical and morphologic findings are quite broad. A bone marrow biopsy may provide diagnostic answers to hematologic or systemic problems that have not…
■ Introduction Bone marrow failure syndromes, defined as peripheral cytopenias due to decreased hematopoiesis in the bone marrow, may be divided into acquired and inherited conditions and further divided into disorders that alter only one hematopoietic lineage (erythroids, myeloids, or…