Guyton and Hall Textbook of Medical Physiology

Aviation, High Altitude, and Space Physiology

As humans have ascended to higher and higher altitudes in aviation, mountain climbing, and space exploration, it has become progressively more important to understand the effects of altitude and low gas pressures on the human body. This chapter deals with…

Regulation of Respiration

The nervous system normally adjusts the rate of alveolar ventilation to meet the demands of the body almost exactly so that the oxygen partial pressure (P o 2 ) and carbon dioxide partial pressure (P co 2 ) in the…

Pulmonary Circulation, Pulmonary Edema, and Pleural Fluid

The lung has two circulations, a high-pressure, low-flow circulation and a low-pressure, high-flow circulation . The high-pressure, low-flow circulation supplies systemic arterial blood to the trachea, bronchial tree (including the terminal bronchioles), supporting tissues of the lung, and outer coats…

Pulmonary Ventilation

The main functions of respiration are to provide oxygen to the tissues and remove carbon dioxide. The four major components of respiration are the following: (1) pulmonary ventilation , which means the inflow and outflow of air between the atmosphere…

Hemostasis and Blood Coagulation

Hemostasis Events The term hemostasis means prevention of blood loss. Whenever a vessel is severed or ruptured, hemostasis is achieved by several mechanisms: (1) vascular constriction; (2) formation of a platelet plug; (3) formation of a blood clot as a…