Introduction Glioblastoma (GBM) is one of the deadliest forms of cancer, with a median survival of approximately 15 months. Standard of care treatment of GBM includes maximal safe surgical resection, fractionated radiotherapy, temozolomide chemotherapy, and, most recently, tumor treatment fields. Despite…
Introduction The goal of modern surgery for glioblastoma is maximal safe resection. Neurosurgeons are keenly aware of the dramatic negative effects that postoperative neurologic deficits have on survival and quality of life. In contrast, achieving a complete or near-complete resection of enhancing…
Preoperative surgical evaluation The initial evaluation of a patient with suspected glioblastoma includes history and physical examination, anatomic imaging, and symptom management with seizure medications and corticosteroids. Clinical presentation of glioblastoma is highly variable, depending on tumor size, location, and…
Given the aggressive nature of glioblastoma, it is nearly a certainty that all patients will need to be evaluated for potential treatment of recurrent disease. There is currently no definitive standard of care for recurrent glioblastoma. Unlike in other solid…
Introduction This chapter reviews the history of angiogenesis and how it was recognized as an essential mechanism for tumor establishment and growth. From the initial recognition of tumor vascularity to the purification of vascular endothelial growth factor (VEGF), this chapter…
Introduction Glioblastoma (GBM), the most common primary brain malignancy, carries a poor prognosis and has therefore been the subject of numerous studies attempting to improve outcomes. Although a plethora of investigative studies and clinical trials have focused on this patient…
Standard-of-care radiation regimens Historical Context of Radiation Therapy and Dose Historically, standard treatment for glioblastoma (GBM) was surgical resection alone. The first randomized trial to show a survival benefit with adjuvant radiation therapy (RT) was the Brain Tumor Study Group…
Acknowledgments The authors would like to acknowledge our colleagues and teachers in neuroradiology at the University of Pennsylvania for their insights on brain tumor imaging, particularly Drs Ronald Wolf, Linda Bagley, Suyash Mohan, and John Woo. Introduction Neuroimaging plays a…
Introduction With an incidence of 3 to 5 per 100,000, glioblastoma fulfills the criteria of a rare cancer. Despite this, glioblastoma is the most common and most aggressive primary brain tumor and accounts for 12% to 15% of all intracranial…
Acknowledgments This work was supported by National Institutes of Health grants R00HL103792 and R01NS094533 , University of Pennsylvania Neuro-oncology Innovation Award, and McCabe Award (to Y. Fan). Glioma is the most common malignant primary tumor in the central nervous system,…