Glioblastoma (GBM) remains the most common primary malignant brain tumor in adults and accounts for 16% of all primary brain tumors and for 45% of malignant primary brain tumors. Despite ample research to find better treatments the prognosis of GBM…
Introduction The cost of cancer treatment has progressively increased over the past decade as newer chemotherapy and immunotherapy agents have been established. Glioblastoma, in particular, has a significant cost in the health care system because of both the severity of…
Introduction Accounting for 52% of all primary brain tumors, glioblastoma is the most common and most aggressive. Glioblastomas account for 20% of all intracranial tumors. Disparities in risk factors, incidence, treatment, and follow-up have been shown in the literature for…
Introduction With a median survival of 12 to 14 months, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. Treatment is therefore not only designed to prolong survival but also to maintain an optimal level of health-related quality of life…
Historical context and biological basis Early detection of solid tumors is vital for extending survival and possibly curing patients with cancer. This idea is especially relevant to patients with the most common and most lethal malignant brain tumor, glioblastoma (GBM), because earlier…
Background Despite trimodal therapy consisting of maximal safe resection and adjuvant partial radiotherapy with concurrent and subsequent temozolomide, glioblastoma (GBM) has a dismal prognosis, with a median survival of 14.6 months and an overall survival of only 9.8% at 5 years. Further…
Introduction The traditional principle in neuro-oncology is to study the tumor first, with little consideration regarding the host; that is, the brain. Nevertheless, to define the optimal therapeutic management for each patient bearing a diffuse glioma (DG), the concept of…
Acknowledgments The authors acknowledge and thank Kisa Zhang for her artwork in Fig. 17.1 . Historical context of electric field treatment The application of physical energy from various parts of the electromagnetic spectrum is common in glioblastoma treatment. The most widely…
The prognosis following diagnosis of glioblastoma remains poor. Historically, there have been many notable attempts to use local drug delivery to treat glioblastoma, including convection-enhanced delivery (CED), direct tumor injection, and the use of to deliver chemotherapeutics. The use of…
Introduction Laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality for brain tumors and other central nervous system (CNS) disorders, first introduced by Bown in 1983, which has been revived over the last 2 decades because of recent…