Essence of Anesthesia Practice

Neurofibromatosis

Risk NF-1 birth incidence: 1:3000 NF-2 birth incidence: 1:25,000 Schwannomatosis incidence: 1:40,000 Perioperative Risks Depend on tumor extent and location Worry About Difficult intubation Intraop Htn Intraop tachycardia Overview NF-1, formerly known as von Recklinghausen disease, is a relatively common,…

Nelson Syndrome

Risk Incidence: Reported in 8–44% of pts following bilateral adrenalectomy for Cushing disease More likely in pts with younger age and pregnancy Perioperative Risks Lyte imbalances DI Vision loss Challenges specific to type of surgery Worry About Panhypopituitarism Volume status…

Necrotizing Fasciitis

Risk Incidence in USA: Approximately 9–11.5 cases of invasive streptococcal infections, from which 1–1.8 die each year STSS and NF, each comprising an average of 6–7% of these invasive cases, with an associated mortality of 35–50% for STSS and 29%…

Necrotizing Enterocolitis

Risk Most common life-threatening intestinal surgical emergency in the newborn. Occurs predominantly in premature infants, with 75% in infants weighing <1500 g. Increasing incidence in term and near-term neonates as well. Perioperative Risks CV instability, acidosis, shock, bowel ischemia, bacteremia,…

Narcolepsy

Risk Prevalence approximately 1:2000 Women and men equally affected Prevalence higher in Japan (1:600) Perioperative Risks Potential for masking or mimicking periop complications Potential deleterious interactions between drugs for narcolepsy and drugs administered periop Worry About There is little evidence…

Myxoma

Risk Although primary cardiac tumors are rare (<0.01%), myxoma is the most common type (50%). 75% develop in LA, with most attached to the interatrial septum. Rarely develop in ventricles. More common in females (70%). Perioperative Risks May be friable…

Myotonia Dystrophica (Myotonic Dystrophy, Steinert Disease)

Risk Incidence of approximately 1:8000. Incidence of the congenital form is higher, with an incidence of 1:100,000 compared with adult-onset form. Perioperative Risks Operative/anesthetic and postop morbidity and mortality are increased and not proportional to severity of disease. High incidence…

Myoclonic Epilepsy With Ragged Red Fibers

Risk Prevalence: 1:400,000 Maternal inheritance; less commonly a spontaneous mitochondrial gene mutation in those without family Hx Perioperative Risks Lactic acidosis Cardiac/respiratory insufficiency/failure Delayed emergence Worry About Respiratory failure following sedation. Consider aspiration risk. Lactic acidosis. Seizures. Overview Mitochondrial myopathy…

Myocarditis

Risk Incidence of idiopathic or viral myocarditis in the general population is unknown. Infectious and noninfectious causes; viruses are the most common. Pts with autoimmune diseases are at increased risk. Perioperative Risks If pt develops DCM: EF <35% increased risk…

Myocardial Ischemia

Risk Incidence in USA: 1.5 million/y develop acute MI; about 50% are silent (without enough symptoms to cause a medical visit); decreased rate of death in the United States balanced by increased population has kept MI numbers constant since 1970…