Acknowledgment We are grateful to Dr. Mark Wick, who was the author of this chapter in earlier editions and was responsible for much of the content in the sections on biology of antigens and antibodies. Overview Tumors of soft tissue…
Introduction During the last two decades, the approach to histopathologic diagnosis has been dramatically transformed by immunohistochemistry, specifically in the diagnosis and classification of tumors and, more recently, in the diagnosis of infectious diseases in tissue samples. Pathologists play an…
Introduction Quality assurance (QA) in immunohistochemistry (IHC) in the era of precision medicine means that IHC assays are set up to be fit-for-purpose. , Although it is without question that precision medicine depends on accurate diagnosis and classification of various…
Overview Immunohistochemistry (IHC), or immunocytochemistry (ICC), is a laboratory technique used to detect specific antigens (i.e., proteins) in tissues or cells based on antigen-antibody recognition; it seeks to exploit the specificity provided by the binding of an antibody with its…