Acknowledgment We would like to acknowledge and thank Jeffrey Goldsmith, MD, for his significant contributions to prior editions of this chapter. This chapter divides the discussion of immunohistochemistry (IHC) of the luminal gastrointestinal (GI) tract into three sections: (1) epithelial…
Overview The skin is a complex microenvironment. The normal structures of the epidermis, dermis, and cutaneous adnexa are morphologically and functionally complicated, and the histologic entities that occur in this tissue compartment are also numerous. Furthermore, cutaneous lesions may also…
The use of immunohistochemistry (IHC) as an aid in the diagnosis of surgical pathology has changed the practice of pathology, as its use is more widespread with more available antibodies to enhance diagnostic specificity. In addition, with the current availability…
Introduction In general, mediastinal pathology is rich in terms of the diversity of neoplasms that may occur primarily in the mediastinal cavity. However, in the context of occurrence, mediastinal tumors are rare. In addition, over the last decades some of…
Acknowledgments We want to thank our former co-authors, Dr. Ronald A. DeLellis and Dr. Sandra J. Shin for their significant contributions to the previous versions of this chapter. Overview Immunohistochemical (IHC) methods have had a profound impact on the understanding…
Acknowledgments My heartfelt appreciation to Ms. Hannah B. Herrera for her reference wrangling. The opinions or assertions contained herein are the private views of the author. Introduction The head and neck, by convention defined as the area above the clavicles…
The impact of diagnostic immunohistochemistry (IHC) for the surgical pathologist is legendary, and it is best appreciated when studying malignancies of unknown primary site. A cost-effective tool, IHC is performed in most hospital laboratories, is often automated, and provides for…
Overview Melanoma continues to represent one of the greatest diagnostic challenges in surgical pathology and is an important source of litigation. Both as a primary lesion in the skin and in metastatic sites, this neoplasm is capable of assuming many…
Only a little more than 30 years ago a popular, widely used classification system for non-Hodgkin lymphomas (NHLs) was initiated based solely on hematoxylin and eosin (H&E)–stained slide interpretation. The “Working Formulation for Clinical Usage” was used for over a…
Overview The hematologic system is complex and includes a diverse range of organs, including the bone marrow, spleen, and lymph nodes. Lymph node disease is covered in Chapter 6 . In this chapter, immunohistochemical evaluation of the bone marrow, spleen,…