Comprehensive Dermatologic Drug Therapy

Hepatotoxicity of Dermatologic Drug Therapy

Questions Q62.1 Concerning various categories of liver disease, what percentage of patients likely have drug causation: (1) adults with hepatitis, (2) adults with hepatitis at least 50-years-old, (3) all patients with fulminant hepatitis? (Pg. 678, Table 62.1 ) Q62.2 What…

Oral Mucosal Therapeutics

Questions Q61.1 Given the various conditions associated with erosive gingivitis, which conditions are best treated with (1) topical corticosteroids alone, (2) topical calcineurin inhibitors, (3) systemic corticosteroids or (4) other immunosuppressive therapies? (Pg. 666) Q61.2 What are some factors which…

Botulinum Toxin Injections

Questions Q60.1 What are the major serotypes of botulinum, and what are the characteristics of botulinum neurotoxin A that make it most suitable for dermatologic use? (Pg. 657) Q60.2 What is the general mechanism by which botulinum toxin relaxes facial…

Injectable Dermal and Subcutaneous Fillers

Questions Q59.1 Which fillers require allergy testing before injection? (Pgs. 651, 653) Q59.2 How does the ‘moldability’ of hyaluronic acid compare with that of calcium hydroxyapatite? (Pg. 651×2) Q59.3 Which fillers can be dissolved if there are undesirable effects? What…

Local Anesthetics

Questions Q58.1 What are some significant differences between commonly used injectable local anesthetics, including properties such as amide versus ester, lipophilicity, etc.? (Pg. 632) Q58.2 What are the advantages and limitations of liposomal bupivacaine? (Pg. 632) Q58.3 What is the…

Miscellaneous Topical Agents

Questions Q57.1 What is the function of endogenous vitamin C, and by what mechanisms does topical vitamin C reportedly reduce clinical findings of photoaging? (Pg. 625) Q57.2 What are the clinical advantages of aluminum chloride used for hemostasis, compared with…

Agents Used for Treatment of Hyperkeratosis

Questions Q55.1 How do salicylic acid and α-hydroxy acids differ regarding lipid solubility and the resultant depth of percutaneous absorption? (Pg. 608) Q55.2 What are some of the mechanisms of salicylic acid leading to keratolytic and desmolytic effects? (Pg. 608)…

Products for the Care of Chronic Wounds

Questions Q54.1 What are the four main stages (and their general sequence) of wound healing? (Pg. 598) Q54.2 What are some of the most important medical conditions to exclude (and related laboratory tests) in patients with a chronic cutaneous ulcer?…

Chemical Peels

Questions Q53.1 What depth of peel is generated using superficial, intermediate, and deep chemical peels? What does frosting during a chemical peel indicate? (Pgs. 592, 593×2, Tables 53.1 and 53.2 ) Q53.2 Why does salicylic acid (SA) penetrate comedones better…