Editor's comment : This new chapter is included in recognition of the increasing power of informatics and data analysis that have become evident in the 21 st century. We are no longer constrained to examining tiny “slices of disease” or…
Funding sources This work was supported by the American Association under grant number 18POST33990293 (BAB) and the National Institutes of Health under grant numbers P01HL051971 (BAB, JPG), P20GM104357 (BAB, JPG), R01HL136684 (JPG), R01HL137791 (EMG), R01HL123527 (EMG), T32HL105324 (JPG), and U54GM115428…
Editors' comment: The short-term maternal and offspring effects of preeclampsia are presented in Chapter 2. This is a new chapter to the fifth edition of Chesley's Hypertensive Disorders in Pregnancy, focusing on long-term health. The topic of remote maternal health…
Editors’ comment: When Dr. Chesley published his original textbook in 1978, tests to predict preeclampsia had hardly been studied. Nevertheless, the concepts of prediction and prevention were never far from his mind. For example, his proposal to use urate clearance as…
Editors' comment: This is a new chapter in the fifth edition of Chesley's Hypertensive Disorders in Pregnancy . The present chapter includes a revision of the previous chapter named “Antihypertensive Treatment” of the fourth edition ( Chapter 19 ), by…
Editors' comment: Following the retirement of Dr. Gary Cunningham from our editorial team after the fourth edition of Chesley's textbook, we have taken the opportunity to update this important chapter on platelet function, coagulation, and hepatic pathophysiology in pregnancy and…
Editors' comment : The role of the renin–angiotensin–aldosterone system (RAAS) in preeclampsia has intrigued investigators for decades. Chesley had a chapter devoted to this topic in his first edition, and he would have been delighted by some of the novel…
Editor's Comment : The Editors gratefully acknowledge the invaluable contributions of Marshall D. Lindheimer, recently retired, who served as Editor and coauthor of this chapter in the second–fourth editions. The revision of the chapter for the current edition (previously Chapter…
Editors' comment : A complete chapter focusing on the brain in normal pregnancy and preeclampsia appeared in Chelsley's third edition, and this is its second revision. The important contributions of previous authors of this chapter, Gerda G. Zeeman and F.…
Editors' comment: In the chapter entitled “Metabolic syndrome and preeclampsia” of the previous (fourth) edition of this textbook, we advanced the concept that components of metabolic syndrome interact with placental factors to promote inflammation, endothelial cell dysfunction, and the maternal…