Adipocytic Tumors There exist a relatively large number of adipocytic tumors, spanning a clinical spectrum from very common benign lipomas, to relatively common atypical lipomatous tumors of borderline malignancy and finally a variety of aggressive and rare liposarcomas. Over the…
The group of so-called fibrohistiocytic tumors encompasses those tumors that were formerly believed to show evidence of hybrid fibroblastic and histiocytic differentiation. In truth, the neoplastic cells in these lesions likely represent either modified fibroblasts/myofibroblasts, or cells of histiocytic lineage,…
Introduction Tumors with myofibroblastic and fibroblastic differentiation comprise an ever-expanding and diverse group of largely spindle cell neoplasms. Some are characterized by recurrent gene fusions, resulting in chimeric transcription factors that initiate proliferative programs driving tumorigenesis and fibrous phenotype, while…
Immunohistochemistry Overview This section covers selected applications of immunohistochemistry (IHC) in the diagnosis of soft tissue and bone neoplasms, emphasizing the applications of IHC to the common differential diagnoses in soft tissue and bone pathology, including: (1) small, blue, round…
Sarcomas are a heterogeneous group of rare mesenchymal malignant tumors. These tumors can arise in all sites of the body and are classified by their line of differentiation according to the type of mature tissue they resemble, either muscle, fat,…